Use of human prolactin as a therapeutic protein to potentiate immunohematopoietic function

Susan M. Richards, William J Murphy

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The conclusion that prolactin plays a role in immune and hematopoietic function was initially based upon observations in hormone deficient animals. The multiple cell function defects associated with hypophysectomy or bromocriptine treatment were reversed by administration of prolactin. Since these initial observations, an increasing body of literature supports prolactin having a role in the immune and hematopoietic system. A recombinant form of human prolactin (r-hPRL) has been produced and evaluated in a wide variety of preclinical models. Both in vitro and in vivo studies suggest that r-hPRL can enhance cell function, accelerate lymphoid and myeloid reconstitution and promote hematopoiesis. The multi-lineage effect of r-hPRL makes it an attractive candidate for clinical situations presenting with immune deficiency or myelosuppression. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)56-62
Number of pages7
JournalJournal of Neuroimmunology
Volume109
Issue number1
DOIs
StatePublished - Sep 1 2000
Externally publishedYes

Keywords

  • Cell function defects
  • Hematopoietic function
  • Immune function
  • Prolactin
  • Therapeutic protein

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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