Abstract
The conclusion that prolactin plays a role in immune and hematopoietic function was initially based upon observations in hormone deficient animals. The multiple cell function defects associated with hypophysectomy or bromocriptine treatment were reversed by administration of prolactin. Since these initial observations, an increasing body of literature supports prolactin having a role in the immune and hematopoietic system. A recombinant form of human prolactin (r-hPRL) has been produced and evaluated in a wide variety of preclinical models. Both in vitro and in vivo studies suggest that r-hPRL can enhance cell function, accelerate lymphoid and myeloid reconstitution and promote hematopoiesis. The multi-lineage effect of r-hPRL makes it an attractive candidate for clinical situations presenting with immune deficiency or myelosuppression. (C) 2000 Elsevier Science B.V.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 56-62 |
| Number of pages | 7 |
| Journal | Journal of Neuroimmunology |
| Volume | 109 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1 2000 |
| Externally published | Yes |
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Keywords
- Cell function defects
- Hematopoietic function
- Immune function
- Prolactin
- Therapeutic protein
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Use of human prolactin as a therapeutic protein to potentiate immunohematopoietic function. / Richards, Susan M.; Murphy, William J.
In: Journal of Neuroimmunology, Vol. 109, No. 1, 01.09.2000, p. 56-62.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use of human prolactin as a therapeutic protein to potentiate immunohematopoietic function
AU - Richards, Susan M.
AU - Murphy, William J
PY - 2000/9/1
Y1 - 2000/9/1
N2 - The conclusion that prolactin plays a role in immune and hematopoietic function was initially based upon observations in hormone deficient animals. The multiple cell function defects associated with hypophysectomy or bromocriptine treatment were reversed by administration of prolactin. Since these initial observations, an increasing body of literature supports prolactin having a role in the immune and hematopoietic system. A recombinant form of human prolactin (r-hPRL) has been produced and evaluated in a wide variety of preclinical models. Both in vitro and in vivo studies suggest that r-hPRL can enhance cell function, accelerate lymphoid and myeloid reconstitution and promote hematopoiesis. The multi-lineage effect of r-hPRL makes it an attractive candidate for clinical situations presenting with immune deficiency or myelosuppression. (C) 2000 Elsevier Science B.V.
AB - The conclusion that prolactin plays a role in immune and hematopoietic function was initially based upon observations in hormone deficient animals. The multiple cell function defects associated with hypophysectomy or bromocriptine treatment were reversed by administration of prolactin. Since these initial observations, an increasing body of literature supports prolactin having a role in the immune and hematopoietic system. A recombinant form of human prolactin (r-hPRL) has been produced and evaluated in a wide variety of preclinical models. Both in vitro and in vivo studies suggest that r-hPRL can enhance cell function, accelerate lymphoid and myeloid reconstitution and promote hematopoiesis. The multi-lineage effect of r-hPRL makes it an attractive candidate for clinical situations presenting with immune deficiency or myelosuppression. (C) 2000 Elsevier Science B.V.
KW - Cell function defects
KW - Hematopoietic function
KW - Immune function
KW - Prolactin
KW - Therapeutic protein
UR - http://www.scopus.com/inward/record.url?scp=0034284090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034284090&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(00)00303-9
DO - 10.1016/S0165-5728(00)00303-9
M3 - Article
C2 - 10969182
AN - SCOPUS:0034284090
VL - 109
SP - 56
EP - 62
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1
ER -