Use of an amphotericin B lipid complex for treatment of blastomycosis in dogs

Donald R. Krawiec, Brendan C. McKiernan, A. Robert Twardock, Christine E. Swenson, Randall J. Itkin, Lynelle R Johnson, Lisa K. Kurowsky, Carol A. Marks

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective - To evaluate efficacy and nephrotoxicity of amphotericin B lipid complex used for treatment of dogs with naturally developing blastomycosis. Design - Prospective clinical trial. Animals - 11 dogs with blastomycosis. Procedure - All dogs were treated with an amphotericin B lipid complex. Two dogs received a cumulative dose of 8 mg/kg of body weight, 1 received a cumulative dose of 10 mg/kg, and 8 received a cumulative dose of 12 mg/kg. Results - The 2 dogs that received a cumulative dose of 8 mg/kg and 1 of the dogs that received a cumulative dose of 12 mg/kg had a relapse of blastomycosis within 30 days of treatment. Seven of the remaining 8 dogs were clinically free of blastomycosis 6 months after treatment. One dog died of an unrelated cause 5.5 months after treatment, but did not have clinical signs of blastomycosis at the time of death. There were not any adverse clinical effects attributable to drug administration in any of the dogs in this study, and none of the dogs developed clinical signs of renal disease or failure. Clinical implications - Amphotericin B lipid complex was a safe and effective treatment for blastomycosis in these dogs.

Original languageEnglish (US)
Pages (from-to)2073-2075
Number of pages3
JournalJournal of the American Veterinary Medical Association
Volume209
Issue number12
StatePublished - Dec 15 1996
Externally publishedYes

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Blastomycosis
blastomycosis
amphotericin B
Dogs
dogs
lipids
dosage
liposomal amphotericin B
nephrotoxicity
relapse
renal failure
kidney diseases
prospective studies

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Krawiec, D. R., McKiernan, B. C., Twardock, A. R., Swenson, C. E., Itkin, R. J., Johnson, L. R., ... Marks, C. A. (1996). Use of an amphotericin B lipid complex for treatment of blastomycosis in dogs. Journal of the American Veterinary Medical Association, 209(12), 2073-2075.

Use of an amphotericin B lipid complex for treatment of blastomycosis in dogs. / Krawiec, Donald R.; McKiernan, Brendan C.; Twardock, A. Robert; Swenson, Christine E.; Itkin, Randall J.; Johnson, Lynelle R; Kurowsky, Lisa K.; Marks, Carol A.

In: Journal of the American Veterinary Medical Association, Vol. 209, No. 12, 15.12.1996, p. 2073-2075.

Research output: Contribution to journalArticle

Krawiec, DR, McKiernan, BC, Twardock, AR, Swenson, CE, Itkin, RJ, Johnson, LR, Kurowsky, LK & Marks, CA 1996, 'Use of an amphotericin B lipid complex for treatment of blastomycosis in dogs', Journal of the American Veterinary Medical Association, vol. 209, no. 12, pp. 2073-2075.
Krawiec DR, McKiernan BC, Twardock AR, Swenson CE, Itkin RJ, Johnson LR et al. Use of an amphotericin B lipid complex for treatment of blastomycosis in dogs. Journal of the American Veterinary Medical Association. 1996 Dec 15;209(12):2073-2075.
Krawiec, Donald R. ; McKiernan, Brendan C. ; Twardock, A. Robert ; Swenson, Christine E. ; Itkin, Randall J. ; Johnson, Lynelle R ; Kurowsky, Lisa K. ; Marks, Carol A. / Use of an amphotericin B lipid complex for treatment of blastomycosis in dogs. In: Journal of the American Veterinary Medical Association. 1996 ; Vol. 209, No. 12. pp. 2073-2075.
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