Abstract
We conducted a community-based study of 457 women aged 18 - 50 years living in eight rural villages in northwest Tanzania. The prevalence of female urogenital schistosomiasis (FUS) was 5% overall but ranged from 0% to 11%. FUS was associated with human immunodeficiency virus (HIV) infection (odds ratio [OR] = 4.0, 95% confidence interval [CI] = 1.2 - 13.5) and younger age (OR = 5.5 and 95% CI = 1.2 - 26.3 for ages < 25 years and OR = 8.2 and 95% CI = 1.7 - 38.4 for ages 25 - 29 years compared with age > 35 years). Overall HIV prevalence was 5.9% but was 17% among women with FUS. We observed significant geographical clustering of schistosomiasis: northern villages near Lake Victoria had more Schistosoma mansoni infections (P < 0.0001), and southern villages farther from the lake had more S. haematobium (P = 0.002). Our data support the postulate that FUS may be a risk factor for HIV infection and may contribute to the extremely high rates of HIV among young women in sub-Saharan Africa.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 364-369 |
| Number of pages | 6 |
| Journal | American Journal of Tropical Medicine and Hygiene |
| Volume | 84 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2011 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Parasitology
- Infectious Diseases
- Virology
- Medicine(all)
Cite this
Urogenital schistosomiasis in women of reproductive age in Tanzania's Lake Victoria region. / Downs, Jennifer A.; Mguta, Charles; Kaatano, Godfrey M.; Mitchell, Katrina B.; Bang, Heejung; Simplice, Harusha; Kalluvya, Samuel E.; Changalucha, John M.; Johnson, Warren D.; Fitzgerald, Daniel W.
In: American Journal of Tropical Medicine and Hygiene, Vol. 84, No. 3, 03.2011, p. 364-369.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Urogenital schistosomiasis in women of reproductive age in Tanzania's Lake Victoria region
AU - Downs, Jennifer A.
AU - Mguta, Charles
AU - Kaatano, Godfrey M.
AU - Mitchell, Katrina B.
AU - Bang, Heejung
AU - Simplice, Harusha
AU - Kalluvya, Samuel E.
AU - Changalucha, John M.
AU - Johnson, Warren D.
AU - Fitzgerald, Daniel W.
PY - 2011/3
Y1 - 2011/3
N2 - We conducted a community-based study of 457 women aged 18 - 50 years living in eight rural villages in northwest Tanzania. The prevalence of female urogenital schistosomiasis (FUS) was 5% overall but ranged from 0% to 11%. FUS was associated with human immunodeficiency virus (HIV) infection (odds ratio [OR] = 4.0, 95% confidence interval [CI] = 1.2 - 13.5) and younger age (OR = 5.5 and 95% CI = 1.2 - 26.3 for ages < 25 years and OR = 8.2 and 95% CI = 1.7 - 38.4 for ages 25 - 29 years compared with age > 35 years). Overall HIV prevalence was 5.9% but was 17% among women with FUS. We observed significant geographical clustering of schistosomiasis: northern villages near Lake Victoria had more Schistosoma mansoni infections (P < 0.0001), and southern villages farther from the lake had more S. haematobium (P = 0.002). Our data support the postulate that FUS may be a risk factor for HIV infection and may contribute to the extremely high rates of HIV among young women in sub-Saharan Africa.
AB - We conducted a community-based study of 457 women aged 18 - 50 years living in eight rural villages in northwest Tanzania. The prevalence of female urogenital schistosomiasis (FUS) was 5% overall but ranged from 0% to 11%. FUS was associated with human immunodeficiency virus (HIV) infection (odds ratio [OR] = 4.0, 95% confidence interval [CI] = 1.2 - 13.5) and younger age (OR = 5.5 and 95% CI = 1.2 - 26.3 for ages < 25 years and OR = 8.2 and 95% CI = 1.7 - 38.4 for ages 25 - 29 years compared with age > 35 years). Overall HIV prevalence was 5.9% but was 17% among women with FUS. We observed significant geographical clustering of schistosomiasis: northern villages near Lake Victoria had more Schistosoma mansoni infections (P < 0.0001), and southern villages farther from the lake had more S. haematobium (P = 0.002). Our data support the postulate that FUS may be a risk factor for HIV infection and may contribute to the extremely high rates of HIV among young women in sub-Saharan Africa.
UR - http://www.scopus.com/inward/record.url?scp=79955660974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955660974&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2011.10-0585
DO - 10.4269/ajtmh.2011.10-0585
M3 - Article
C2 - 21363971
AN - SCOPUS:79955660974
VL - 84
SP - 364
EP - 369
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 3
ER -