Abstract
Acute infections can increase the risk of vitamin A deficiency in young children. To determine the extent of urinary vitamin A loss and the factors associated with such loss in shigellosis, 66 hospitalized children aged 5 mo to 5 yr were studied in Bangladesh. Subjects excreted up to 0.63 μmol retinol/day, with 8% of children excreting ≥ 20% of the daily metabolic requirement of 0.70 μmol. Retinol excretion (μmol/day) was significantly higher in children with S. dysenteriae type 1 infection (0.048 ± 0.127 vs. 0.002 ± 0.005, p = 0.0003), and fever > 38.5° C (0.061 ± 0.140 vs. 0.002 ± 0.007, p < 0.0001). In a multiple regression analysis, body temperature (β =0.1029, p = 0.04), creatinine clearance (β = 0.0086, p = 0.009), and tubular reabsorption of β2-microglobulin (β = -0.2971, p < 0.0001) were significant predictors of retinol excretion, while tubular reabsorption of retinol-binding protein and phosphate, urinary albumin concentration, weight-for-age, Shigella type, and age were not. In conclusion, fever and changes in kidney function are independent predictors of urinary retinol loss in children with shigellosis.
| Original language | English (US) |
|---|---|
| Journal | FASEB Journal |
| Volume | 11 |
| Issue number | 3 |
| State | Published - 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
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Urinary vitamin A loss in children with acute shigellosis. / Mitra, A. K.; Alvarez, J. Q.; Wahed, M. A.; Fuchs, G. J.; Guay-Woodford, L.; Stephensen, C. B.
In: FASEB Journal, Vol. 11, No. 3, 1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Urinary vitamin A loss in children with acute shigellosis
AU - Mitra, A. K.
AU - Alvarez, J. Q.
AU - Wahed, M. A.
AU - Fuchs, G. J.
AU - Guay-Woodford, L.
AU - Stephensen, C. B.
PY - 1997
Y1 - 1997
N2 - Acute infections can increase the risk of vitamin A deficiency in young children. To determine the extent of urinary vitamin A loss and the factors associated with such loss in shigellosis, 66 hospitalized children aged 5 mo to 5 yr were studied in Bangladesh. Subjects excreted up to 0.63 μmol retinol/day, with 8% of children excreting ≥ 20% of the daily metabolic requirement of 0.70 μmol. Retinol excretion (μmol/day) was significantly higher in children with S. dysenteriae type 1 infection (0.048 ± 0.127 vs. 0.002 ± 0.005, p = 0.0003), and fever > 38.5° C (0.061 ± 0.140 vs. 0.002 ± 0.007, p < 0.0001). In a multiple regression analysis, body temperature (β =0.1029, p = 0.04), creatinine clearance (β = 0.0086, p = 0.009), and tubular reabsorption of β2-microglobulin (β = -0.2971, p < 0.0001) were significant predictors of retinol excretion, while tubular reabsorption of retinol-binding protein and phosphate, urinary albumin concentration, weight-for-age, Shigella type, and age were not. In conclusion, fever and changes in kidney function are independent predictors of urinary retinol loss in children with shigellosis.
AB - Acute infections can increase the risk of vitamin A deficiency in young children. To determine the extent of urinary vitamin A loss and the factors associated with such loss in shigellosis, 66 hospitalized children aged 5 mo to 5 yr were studied in Bangladesh. Subjects excreted up to 0.63 μmol retinol/day, with 8% of children excreting ≥ 20% of the daily metabolic requirement of 0.70 μmol. Retinol excretion (μmol/day) was significantly higher in children with S. dysenteriae type 1 infection (0.048 ± 0.127 vs. 0.002 ± 0.005, p = 0.0003), and fever > 38.5° C (0.061 ± 0.140 vs. 0.002 ± 0.007, p < 0.0001). In a multiple regression analysis, body temperature (β =0.1029, p = 0.04), creatinine clearance (β = 0.0086, p = 0.009), and tubular reabsorption of β2-microglobulin (β = -0.2971, p < 0.0001) were significant predictors of retinol excretion, while tubular reabsorption of retinol-binding protein and phosphate, urinary albumin concentration, weight-for-age, Shigella type, and age were not. In conclusion, fever and changes in kidney function are independent predictors of urinary retinol loss in children with shigellosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=7144243468&partnerID=8YFLogxK
M3 - Article
VL - 11
JO - FASEB Journal
JF - FASEB Journal
SN - 0892-6638
IS - 3
ER -