Urinary vitamin A loss in children with acute shigellosis

A. K. Mitra, J. Q. Alvarez, M. A. Wahed, G. J. Fuchs, L. Guay-Woodford, C. B. Stephensen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Acute infections can increase the risk of vitamin A deficiency in young children. To determine the extent of urinary vitamin A loss and the factors associated with such loss in shigellosis, 66 hospitalized children aged 5 mo to 5 yr were studied in Bangladesh. Subjects excreted up to 0.63 μmol retinol/day, with 8% of children excreting ≥ 20% of the daily metabolic requirement of 0.70 μmol. Retinol excretion (μmol/day) was significantly higher in children with S. dysenteriae type 1 infection (0.048 ± 0.127 vs. 0.002 ± 0.005, p = 0.0003), and fever > 38.5° C (0.061 ± 0.140 vs. 0.002 ± 0.007, p < 0.0001). In a multiple regression analysis, body temperature (β =0.1029, p = 0.04), creatinine clearance (β = 0.0086, p = 0.009), and tubular reabsorption of β2-microglobulin (β = -0.2971, p < 0.0001) were significant predictors of retinol excretion, while tubular reabsorption of retinol-binding protein and phosphate, urinary albumin concentration, weight-for-age, Shigella type, and age were not. In conclusion, fever and changes in kidney function are independent predictors of urinary retinol loss in children with shigellosis.

Original languageEnglish (US)
JournalFASEB Journal
Issue number3
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology


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