Urinary vitamin A loss in children with acute shigellosis

A. K. Mitra, J. Q. Alvarez, M. A. Wahed, G. J. Fuchs, L. Guay-Woodford, C. B. Stephensen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Acute infections can increase the risk of vitamin A deficiency in young children. To determine the extent of urinary vitamin A loss and the factors associated with such loss in shigellosis, 66 hospitalized children aged 5 mo to 5 yr were studied in Bangladesh. Subjects excreted up to 0.63 μmol retinol/day, with 8% of children excreting ≥ 20% of the daily metabolic requirement of 0.70 μmol. Retinol excretion (μmol/day) was significantly higher in children with S. dysenteriae type 1 infection (0.048 ± 0.127 vs. 0.002 ± 0.005, p = 0.0003), and fever > 38.5° C (0.061 ± 0.140 vs. 0.002 ± 0.007, p < 0.0001). In a multiple regression analysis, body temperature (β =0.1029, p = 0.04), creatinine clearance (β = 0.0086, p = 0.009), and tubular reabsorption of β2-microglobulin (β = -0.2971, p < 0.0001) were significant predictors of retinol excretion, while tubular reabsorption of retinol-binding protein and phosphate, urinary albumin concentration, weight-for-age, Shigella type, and age were not. In conclusion, fever and changes in kidney function are independent predictors of urinary retinol loss in children with shigellosis.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

shigellosis
Bacillary Dysentery
Vitamin A
vitamin A
fever
Fever
excretion
Vitamin A Deficiency
Retinol-Binding Proteins
retinol-binding protein
Shigella
Hospitalized Child
vitamin A deficiency
Bangladesh
renal function
Infection
Body Temperature
infection
creatinine
body temperature

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Mitra, A. K., Alvarez, J. Q., Wahed, M. A., Fuchs, G. J., Guay-Woodford, L., & Stephensen, C. B. (1997). Urinary vitamin A loss in children with acute shigellosis. FASEB Journal, 11(3).

Urinary vitamin A loss in children with acute shigellosis. / Mitra, A. K.; Alvarez, J. Q.; Wahed, M. A.; Fuchs, G. J.; Guay-Woodford, L.; Stephensen, C. B.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Mitra, AK, Alvarez, JQ, Wahed, MA, Fuchs, GJ, Guay-Woodford, L & Stephensen, CB 1997, 'Urinary vitamin A loss in children with acute shigellosis', FASEB Journal, vol. 11, no. 3.
Mitra AK, Alvarez JQ, Wahed MA, Fuchs GJ, Guay-Woodford L, Stephensen CB. Urinary vitamin A loss in children with acute shigellosis. FASEB Journal. 1997;11(3).
Mitra, A. K. ; Alvarez, J. Q. ; Wahed, M. A. ; Fuchs, G. J. ; Guay-Woodford, L. ; Stephensen, C. B. / Urinary vitamin A loss in children with acute shigellosis. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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