Urinary felinine excretion in intact male cats is increased by dietary cystine

Wouter H. Hendriks, Kay J. Rutherfurd-Markwick, Karin Weidgraaf, R. Hugh Morton, Quinton Rogers

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Felinine is a branched-chain sulfur amino acid present in the urine of certain Felidae, including domestic cats. The objective of the present study was to determine if additional cystine and/or dietary N would increase felinine and N-acetylfelinine excretion by intact male cats fed a low-protein (LP) diet. Feeding five adult intact male cats an LP diet (18.8% of metabolisable energy (ME) as protein) v. a high-protein diet (38.6% of ME as protein) resulted in a trend (P = 0.08) for decreased urinary felinine and no change in N-acetylfelinine excretion. In a 23 d study, when the LP diet was supplemented with l-cystine at 9.3 g/kg DM, urinary felinine:creatinine ratio showed a linear two-fold (121 %) increase (P < 0.01) from 0.24 (sem 0.05) to 0.53 (sem 0.13) after 10 d. Subsequent feeding of the LP diet resulted in a decrease in felinine excretion to base levels. Plasma γ-glutamylfelinylglycine concentrations were consistent with the excretion of felinine. Supplementation of the LP diet with L-cystine (9.3 g/kg DM), dispensable amino acids and arginine to a second group (n 5) also resulted in a significant (P < 0.01) but smaller (+72%) increase in the daily felinine:creatinine ratio (0.25 (sem 0.04) to 0.43 (sem 0.05)). The degree of felinine N-acetylation within groups was unaffected by dietary addition and withdrawal of amino acids. The results indicate that felinine synthesis is regulated by cystine availability, and that arginine may be physiologically important in decreasing felinine biosynthesis in intact male cats.

Original languageEnglish (US)
Pages (from-to)801-809
Number of pages9
JournalBritish Journal of Nutrition
Volume100
Issue number4
DOIs
StatePublished - Sep 19 2008

Fingerprint

Cystine
Cats
Protein-Restricted Diet
Arginine
felinine
Creatinine
Sulfur Amino Acids
Amino Acids
Branched Chain Amino Acids
Proteins
Felidae
Acetylation
Urine

Keywords

  • Arginine
  • Cats
  • Cysteine
  • Felinine
  • N-acetylfelinine

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Urinary felinine excretion in intact male cats is increased by dietary cystine. / Hendriks, Wouter H.; Rutherfurd-Markwick, Kay J.; Weidgraaf, Karin; Morton, R. Hugh; Rogers, Quinton.

In: British Journal of Nutrition, Vol. 100, No. 4, 19.09.2008, p. 801-809.

Research output: Contribution to journalArticle

Hendriks, WH, Rutherfurd-Markwick, KJ, Weidgraaf, K, Morton, RH & Rogers, Q 2008, 'Urinary felinine excretion in intact male cats is increased by dietary cystine', British Journal of Nutrition, vol. 100, no. 4, pp. 801-809. https://doi.org/10.1017/S0007114508945165
Hendriks, Wouter H. ; Rutherfurd-Markwick, Kay J. ; Weidgraaf, Karin ; Morton, R. Hugh ; Rogers, Quinton. / Urinary felinine excretion in intact male cats is increased by dietary cystine. In: British Journal of Nutrition. 2008 ; Vol. 100, No. 4. pp. 801-809.
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