Urinary effects of morphine in preterm infants

B. O S Bengtsson, S. L. Wootton-Gorges, Francis R Poulain, Michael P. Sherman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Aim: To describe the association between morphine administration in preterm infants, hydronephrosis, and renal dysfunction. Methods: The findings were based on serial ultrasound examinations and blood studies. Results: Two preterm infants had bladder distension and hydronephrosis after they received intravenous morphine for analgesia. Morphine was used at a low dose. Each patient had a normal urine output and normal serum creatinine before the signs and symptoms of urinary retention were observed. Within 24 h of morphine administration, each infant concurrently developed oliguria and elevation of the serum creatinine. Cessation of morphine and urinary drainage resulted in rapid and complete resolution of the hydronephrosis and the elevated creatinine. Conclusion: Morphine, even at low dosages, can be associated with hydronephrosis in hospitalized preterm infants.

Original languageEnglish (US)
Pages (from-to)251-253
Number of pages3
JournalActa Paediatrica, International Journal of Paediatrics
Issue number2
StatePublished - 2003


  • Bladder distension
  • Creatinine
  • Hydronephrosis
  • Oliguria
  • Ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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