Urinary biomarkers of catechins and risk of hepatocellular carcinoma in the shanghai cohort study

Lesley M. Butler, Joyce Yongxu Huang, Renwei Wang, Mao Jun Lee, Chung S. Yang, Yu Tang Gao, Jian Min Yuan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Dietary catechins are phytochemicals with both antioxidative and prooxidative stress properties. Green tea is a major source of catechins and may be associated with hepatocellular carcinoma (HCC) risk, but the catechin-HCC relationship has not been evaluated using a biomarker-based approach. A nested case-control study of HCC (211 cases and 1,067 matched controls) was conducted within the Shanghai Cohort Study, which enrolled 18,244 men between 1986 and 1989. Concentrations of specific catechins, including epicatechin, epigallocatechin (EGC), and 4′-O-methyl-epigallocatechin, were measured in urine specimens that had been collected prior to HCC diagnosis. None of the catechins measured were associated with HCC risk. In stratified analyses, there was a statistically significant trend for an association of higher urinary EGC with increased HCC risk among subjects with positive serology for hepatitis B surface antigen (P for trend = 0.02). This positive EGC-HCC association became stronger for hepatitis B surface antigen-positive persons who also had low serum retinol levels (for detectable levels vs. undetectable levels, odds ratio = 2.62, 95% confidence interval: 1.25, 5.51). There was no evidence supporting a protective role of catechins in the development of HCC. Instead, exposure to high levels of catechins may increase the risk of developing HCC for high-risk individuals.

Original languageEnglish (US)
Pages (from-to)397-405
Number of pages9
JournalAmerican Journal of Epidemiology
Volume181
Issue number6
DOIs
StatePublished - Dec 8 2014
Externally publishedYes

Fingerprint

Catechin
Hepatocellular Carcinoma
Cohort Studies
Biomarkers
Hepatitis B Surface Antigens
Phytochemicals
Tea
Serology
Vitamin A
Case-Control Studies
Odds Ratio
Urine
Confidence Intervals

Keywords

  • catechins
  • flavonoids
  • green tea
  • hepatocellular carcinoma
  • retinol

ASJC Scopus subject areas

  • Epidemiology

Cite this

Butler, L. M., Huang, J. Y., Wang, R., Lee, M. J., Yang, C. S., Gao, Y. T., & Yuan, J. M. (2014). Urinary biomarkers of catechins and risk of hepatocellular carcinoma in the shanghai cohort study. American Journal of Epidemiology, 181(6), 397-405. https://doi.org/10.1093/aje/kwu304

Urinary biomarkers of catechins and risk of hepatocellular carcinoma in the shanghai cohort study. / Butler, Lesley M.; Huang, Joyce Yongxu; Wang, Renwei; Lee, Mao Jun; Yang, Chung S.; Gao, Yu Tang; Yuan, Jian Min.

In: American Journal of Epidemiology, Vol. 181, No. 6, 08.12.2014, p. 397-405.

Research output: Contribution to journalArticle

Butler, LM, Huang, JY, Wang, R, Lee, MJ, Yang, CS, Gao, YT & Yuan, JM 2014, 'Urinary biomarkers of catechins and risk of hepatocellular carcinoma in the shanghai cohort study', American Journal of Epidemiology, vol. 181, no. 6, pp. 397-405. https://doi.org/10.1093/aje/kwu304
Butler, Lesley M. ; Huang, Joyce Yongxu ; Wang, Renwei ; Lee, Mao Jun ; Yang, Chung S. ; Gao, Yu Tang ; Yuan, Jian Min. / Urinary biomarkers of catechins and risk of hepatocellular carcinoma in the shanghai cohort study. In: American Journal of Epidemiology. 2014 ; Vol. 181, No. 6. pp. 397-405.
@article{9f1a52b19be547359a86f0bb81aecf92,
title = "Urinary biomarkers of catechins and risk of hepatocellular carcinoma in the shanghai cohort study",
abstract = "Dietary catechins are phytochemicals with both antioxidative and prooxidative stress properties. Green tea is a major source of catechins and may be associated with hepatocellular carcinoma (HCC) risk, but the catechin-HCC relationship has not been evaluated using a biomarker-based approach. A nested case-control study of HCC (211 cases and 1,067 matched controls) was conducted within the Shanghai Cohort Study, which enrolled 18,244 men between 1986 and 1989. Concentrations of specific catechins, including epicatechin, epigallocatechin (EGC), and 4′-O-methyl-epigallocatechin, were measured in urine specimens that had been collected prior to HCC diagnosis. None of the catechins measured were associated with HCC risk. In stratified analyses, there was a statistically significant trend for an association of higher urinary EGC with increased HCC risk among subjects with positive serology for hepatitis B surface antigen (P for trend = 0.02). This positive EGC-HCC association became stronger for hepatitis B surface antigen-positive persons who also had low serum retinol levels (for detectable levels vs. undetectable levels, odds ratio = 2.62, 95{\%} confidence interval: 1.25, 5.51). There was no evidence supporting a protective role of catechins in the development of HCC. Instead, exposure to high levels of catechins may increase the risk of developing HCC for high-risk individuals.",
keywords = "catechins, flavonoids, green tea, hepatocellular carcinoma, retinol",
author = "Butler, {Lesley M.} and Huang, {Joyce Yongxu} and Renwei Wang and Lee, {Mao Jun} and Yang, {Chung S.} and Gao, {Yu Tang} and Yuan, {Jian Min}",
year = "2014",
month = "12",
day = "8",
doi = "10.1093/aje/kwu304",
language = "English (US)",
volume = "181",
pages = "397--405",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Urinary biomarkers of catechins and risk of hepatocellular carcinoma in the shanghai cohort study

AU - Butler, Lesley M.

AU - Huang, Joyce Yongxu

AU - Wang, Renwei

AU - Lee, Mao Jun

AU - Yang, Chung S.

AU - Gao, Yu Tang

AU - Yuan, Jian Min

PY - 2014/12/8

Y1 - 2014/12/8

N2 - Dietary catechins are phytochemicals with both antioxidative and prooxidative stress properties. Green tea is a major source of catechins and may be associated with hepatocellular carcinoma (HCC) risk, but the catechin-HCC relationship has not been evaluated using a biomarker-based approach. A nested case-control study of HCC (211 cases and 1,067 matched controls) was conducted within the Shanghai Cohort Study, which enrolled 18,244 men between 1986 and 1989. Concentrations of specific catechins, including epicatechin, epigallocatechin (EGC), and 4′-O-methyl-epigallocatechin, were measured in urine specimens that had been collected prior to HCC diagnosis. None of the catechins measured were associated with HCC risk. In stratified analyses, there was a statistically significant trend for an association of higher urinary EGC with increased HCC risk among subjects with positive serology for hepatitis B surface antigen (P for trend = 0.02). This positive EGC-HCC association became stronger for hepatitis B surface antigen-positive persons who also had low serum retinol levels (for detectable levels vs. undetectable levels, odds ratio = 2.62, 95% confidence interval: 1.25, 5.51). There was no evidence supporting a protective role of catechins in the development of HCC. Instead, exposure to high levels of catechins may increase the risk of developing HCC for high-risk individuals.

AB - Dietary catechins are phytochemicals with both antioxidative and prooxidative stress properties. Green tea is a major source of catechins and may be associated with hepatocellular carcinoma (HCC) risk, but the catechin-HCC relationship has not been evaluated using a biomarker-based approach. A nested case-control study of HCC (211 cases and 1,067 matched controls) was conducted within the Shanghai Cohort Study, which enrolled 18,244 men between 1986 and 1989. Concentrations of specific catechins, including epicatechin, epigallocatechin (EGC), and 4′-O-methyl-epigallocatechin, were measured in urine specimens that had been collected prior to HCC diagnosis. None of the catechins measured were associated with HCC risk. In stratified analyses, there was a statistically significant trend for an association of higher urinary EGC with increased HCC risk among subjects with positive serology for hepatitis B surface antigen (P for trend = 0.02). This positive EGC-HCC association became stronger for hepatitis B surface antigen-positive persons who also had low serum retinol levels (for detectable levels vs. undetectable levels, odds ratio = 2.62, 95% confidence interval: 1.25, 5.51). There was no evidence supporting a protective role of catechins in the development of HCC. Instead, exposure to high levels of catechins may increase the risk of developing HCC for high-risk individuals.

KW - catechins

KW - flavonoids

KW - green tea

KW - hepatocellular carcinoma

KW - retinol

UR - http://www.scopus.com/inward/record.url?scp=84924428396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924428396&partnerID=8YFLogxK

U2 - 10.1093/aje/kwu304

DO - 10.1093/aje/kwu304

M3 - Article

C2 - 25713334

AN - SCOPUS:84924428396

VL - 181

SP - 397

EP - 405

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 6

ER -