Urinary basic fibroblast growth factor: A biochemical marker for preosseous fibroproliferative lesions in patients with fibrodysplasia ossificans progressiva

Frederick Kaplan, Jeffrey Sawyer, Susan Connors, Karen Keough, Eileen Shore, Francis Gannon, David Glaser, David M Rocke, Michael Zasloff, Judah Folkman

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Angiogenesis is a prominent histopathologic feature of preosseous fibroproliferative lesions in patients who have fibrodysplasia ossificans progressiva. Basic fibroblast growth factor is an extremely potent in vivo stimulator of angiogenesis, and has been implicated in the growth of solid tumors. An enzyme linked immunosorbent assay for basic fibroblast growth factor was performed on urine samples from patients who had active (n = 28) and inactive (n = 39) fibrodysplasia ossificans progressiva, and compare with urine samples from normal age and gender matched control subjects (n = 54). Median basic fibroblast growth factor levels were 2705 pg/g of creatinine in the normal control group, 5058 pg/g of creatinine in patients with inactive fibrodysplasia ossificans progressiva (no significant difference), and 8793 pg/g of creatinine in patients with active fibrodysplasia ossificans progressiva. Female subjects, both normal and with fibrodysplasia ossificans progressiva, had higher levels of urinary basic fibroblast growth factor than did male subjects. There was no correlation of urinary basic fibroblast growth factor levels with age or severity of preexisting disability. These data document an elevation of urinary basic fibroblast growth factor during acute flareups of fibrodysplasia ossificans progressiva and provide a biochemical basis for considering antiangiogenic therapy for inhibiting endochondral osteogenesis in this disorder.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalClinical Orthopaedics and Related Research
Issue number346
StatePublished - Jan 1998

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'Urinary basic fibroblast growth factor: A biochemical marker for preosseous fibroproliferative lesions in patients with fibrodysplasia ossificans progressiva'. Together they form a unique fingerprint.

  • Cite this