Abstract
The accumulation of an Indium-111-labeled monoclonal antibody (MoAb), ZME-018, in melanoma tumors in a patient was determined by sequential, quantitative gamma camera imaging. The amount and concentration of In-111 in each tumor changed in a characteristic pattern with time, reaching a peak at day 3 followed by a steady clearance. The concentration of In-111 in the tumor and the ratios of tumor to whole-body or blood decreased as the size of the tumor increased. These results were interpreted to indicate that the fraction of active, perfused tumor decreased as the melanoma lesions increased in size. The maximum number of MoAb molecules bound per melanoma cell was calculated to be about 35,000. The implications of these observations for radioimmunoimaging and therapy are significant.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | American Journal of Physiologic Imaging |
| Volume | 3 |
| Issue number | 1 |
| State | Published - 1988 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
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Uptake of indium-111-labeled monoclonal antibody ZME-018 as a function of tumor size in a patient with melanoma. / Macey, D. J.; Denardo, S. J.; Denardo, Gerald L; Goodnight Jr, James E; Unger, M. W.
In: American Journal of Physiologic Imaging, Vol. 3, No. 1, 1988, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Uptake of indium-111-labeled monoclonal antibody ZME-018 as a function of tumor size in a patient with melanoma
AU - Macey, D. J.
AU - Denardo, S. J.
AU - Denardo, Gerald L
AU - Goodnight Jr, James E
AU - Unger, M. W.
PY - 1988
Y1 - 1988
N2 - The accumulation of an Indium-111-labeled monoclonal antibody (MoAb), ZME-018, in melanoma tumors in a patient was determined by sequential, quantitative gamma camera imaging. The amount and concentration of In-111 in each tumor changed in a characteristic pattern with time, reaching a peak at day 3 followed by a steady clearance. The concentration of In-111 in the tumor and the ratios of tumor to whole-body or blood decreased as the size of the tumor increased. These results were interpreted to indicate that the fraction of active, perfused tumor decreased as the melanoma lesions increased in size. The maximum number of MoAb molecules bound per melanoma cell was calculated to be about 35,000. The implications of these observations for radioimmunoimaging and therapy are significant.
AB - The accumulation of an Indium-111-labeled monoclonal antibody (MoAb), ZME-018, in melanoma tumors in a patient was determined by sequential, quantitative gamma camera imaging. The amount and concentration of In-111 in each tumor changed in a characteristic pattern with time, reaching a peak at day 3 followed by a steady clearance. The concentration of In-111 in the tumor and the ratios of tumor to whole-body or blood decreased as the size of the tumor increased. These results were interpreted to indicate that the fraction of active, perfused tumor decreased as the melanoma lesions increased in size. The maximum number of MoAb molecules bound per melanoma cell was calculated to be about 35,000. The implications of these observations for radioimmunoimaging and therapy are significant.
UR - http://www.scopus.com/inward/record.url?scp=0023947788&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023947788&partnerID=8YFLogxK
M3 - Article
C2 - 3390350
AN - SCOPUS:0023947788
VL - 3
SP - 1
EP - 6
JO - American Journal of Physiologic Imaging
JF - American Journal of Physiologic Imaging
SN - 0885-8276
IS - 1
ER -