Upper-extremity H-reflex measurement post-stroke: Reliability and inter-limb differences

Chetan P. Phadke, Christopher T. Robertson, Elizabeth G. Condliffe, Carolynn Patten

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To establish test-retest reliability of flexor carpi radialis (FCR) H-reflexes in non-disabled and stroke participants. We also investigated inter-limb differences and effects of chronicity post-stroke compared to non-disabled group and age-related effects in the non-disabled group. Methods: Sixteen chronic stroke and twenty-two non-disabled participants were recruited. Bilateral FCR H-reflexes were tested on two separate days by stimulating the median nerve and recording surface electromyography responses. FCR recruitment curves were plotted for H-reflex (H) and motor (M) waves and normalized as a percentage of maximal M-wave (ordinate) and motor threshold (abscissa). Statistics: Intraclass correlation coefficients [two-way mixed model-ICC (1, 2)], one-way ANOVA, Bland-Altman plots, standard error of measurement (SEM), and smallest real difference (SRD). Results: ICCs ranged from 0.55 to 0.95 (stroke) and 0.69-0.88 (non-disabled). SEM% (% of the mean) ranged from 9% to 24% (stroke) and 18-38% (non-disabled); SRD% ranged from 18% to 66% (stroke) and 6% to 50% (non-disabled). H-reflex amplitude and slope were greater in the paretic vs. non-paretic arm post-stroke (p= 0.07 and 0.01, respectively) and the paretic arm vs. non-disabled participants (p= 0.007 and 0.002, respectively). Stroke participants with longer chronicity (mean 9.4. years) revealed a significantly greater Hslp/Mslp on the paretic side compared to shorter chronicity (2.5. years; p= 0.05). Mean Hslp/Mslp was significantly greater in the young (mean 29. years) compared to the older group (62. years; p= 0.045). Conclusions: These results establish reliability of FCR H-reflexes in stroke and non-disabled participants. SEM and SRD measurements can be used to interpret recovery patterns and longitudinal effects of therapeutic interventions. Significance: FCR H-reflex amplitude and slope can be reliably measured and used to investigate neurophysiological mechanisms of motor recovery post-stroke.

Original languageEnglish (US)
Pages (from-to)1606-1615
Number of pages10
JournalClinical Neurophysiology
Volume123
Issue number8
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

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H-Reflex
Upper Extremity
Extremities
Stroke
Reproducibility of Results
Arm
Median Nerve
Electromyography
Therapeutic Uses
Analysis of Variance
Age Groups

Keywords

  • Recovery
  • Reflex
  • Reliability
  • Stroke
  • Upper-extremity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Upper-extremity H-reflex measurement post-stroke : Reliability and inter-limb differences. / Phadke, Chetan P.; Robertson, Christopher T.; Condliffe, Elizabeth G.; Patten, Carolynn.

In: Clinical Neurophysiology, Vol. 123, No. 8, 01.08.2012, p. 1606-1615.

Research output: Contribution to journalArticle

Phadke, Chetan P. ; Robertson, Christopher T. ; Condliffe, Elizabeth G. ; Patten, Carolynn. / Upper-extremity H-reflex measurement post-stroke : Reliability and inter-limb differences. In: Clinical Neurophysiology. 2012 ; Vol. 123, No. 8. pp. 1606-1615.
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AU - Condliffe, Elizabeth G.

AU - Patten, Carolynn

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N2 - Objective: To establish test-retest reliability of flexor carpi radialis (FCR) H-reflexes in non-disabled and stroke participants. We also investigated inter-limb differences and effects of chronicity post-stroke compared to non-disabled group and age-related effects in the non-disabled group. Methods: Sixteen chronic stroke and twenty-two non-disabled participants were recruited. Bilateral FCR H-reflexes were tested on two separate days by stimulating the median nerve and recording surface electromyography responses. FCR recruitment curves were plotted for H-reflex (H) and motor (M) waves and normalized as a percentage of maximal M-wave (ordinate) and motor threshold (abscissa). Statistics: Intraclass correlation coefficients [two-way mixed model-ICC (1, 2)], one-way ANOVA, Bland-Altman plots, standard error of measurement (SEM), and smallest real difference (SRD). Results: ICCs ranged from 0.55 to 0.95 (stroke) and 0.69-0.88 (non-disabled). SEM% (% of the mean) ranged from 9% to 24% (stroke) and 18-38% (non-disabled); SRD% ranged from 18% to 66% (stroke) and 6% to 50% (non-disabled). H-reflex amplitude and slope were greater in the paretic vs. non-paretic arm post-stroke (p= 0.07 and 0.01, respectively) and the paretic arm vs. non-disabled participants (p= 0.007 and 0.002, respectively). Stroke participants with longer chronicity (mean 9.4. years) revealed a significantly greater Hslp/Mslp on the paretic side compared to shorter chronicity (2.5. years; p= 0.05). Mean Hslp/Mslp was significantly greater in the young (mean 29. years) compared to the older group (62. years; p= 0.045). Conclusions: These results establish reliability of FCR H-reflexes in stroke and non-disabled participants. SEM and SRD measurements can be used to interpret recovery patterns and longitudinal effects of therapeutic interventions. Significance: FCR H-reflex amplitude and slope can be reliably measured and used to investigate neurophysiological mechanisms of motor recovery post-stroke.

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KW - Recovery

KW - Reflex

KW - Reliability

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