Update on the immunological mechanism of action behind phototherapy

Danielle Tartar, Tina Bhutani, Monica Huynh, Timothy Berger, John Koo

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Phototherapy is often used to treat inflammatory skin conditions such as psoriasis and eczema. Much progress has recently been made in understanding the mechanisms underlying the local, cutaneous immune effects induced by phototherapy. Unlike many immunosuppressive drugs used in the management of inflammatory skin disease, phototherapy not only targets effector immune cells but also appears to up-regulate regulatoryT cells (Tregs). Additionally, phototherapy reverses epidermal barrier abnormalities common in these diseases, allowing for restoration of cutaneous homeostasis.

Original languageEnglish (US)
Pages (from-to)564-568
Number of pages5
JournalJournal of Drugs in Dermatology
Volume13
Issue number5
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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    Tartar, D., Bhutani, T., Huynh, M., Berger, T., & Koo, J. (2014). Update on the immunological mechanism of action behind phototherapy. Journal of Drugs in Dermatology, 13(5), 564-568.