Update on laser photochemotherapy: An alternative for cancer treatment

Marcos B. Paiva, Jayne S Joo, Marcio Abrahão, Joao Carlos Ribeiro, Onivaldo Cervantes, Joel A. Sercarz

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Although major progress has been made in surgery, radiation, and chemotherapy for the treatment of malignancy during the last 20 years, there has been little improvement in the survival of patients with recurrent or advanced head and neck cancer. Because of the ease and accessibility for surgery and their loco-regional biological behavior, head and neck cancers serve as an ideal model to test combined laser energy delivered via interstitial fiberoptics and chemotherapeutic agents activated by photo-thermal energy as an alternative, less invasive treatment for cancer. A number of investigators have shown that anthracyclines and cisplatin are likely candidates for light or heat activation in cancer cells. Maximum tolerated dose followed by photochemical and thermal activation via laser fiberoptics can improve treatment by sensitizing tumor response. The higher intratumor drug levels compared to systemic drug administration along with laser activation should also reduce systemic toxicity. In this article the authors analyze the concept of combining anti-cancer drugs and laser therapy and review the clinical application. In summary, the literature available suggests photochemotherapy with currently approved drugs and lasers may soon become an attractive alternative for cancer treatment.

Original languageEnglish (US)
Pages (from-to)772-779
Number of pages8
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume11
Issue number8
StatePublished - Oct 2011

Fingerprint

Photochemotherapy
Lasers
Neoplasms
Hot Temperature
Head and Neck Neoplasms
Therapeutics
Pharmaceutical Preparations
Drug Therapy
Maximum Tolerated Dose
Anthracyclines
Laser Therapy
Cisplatin
Research Personnel
Radiation
Light
Survival

Keywords

  • Cisplatin
  • Combined intratumor therapy
  • Laser-induced thermal therapy
  • Lasers
  • Photochemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pharmacology

Cite this

Paiva, M. B., Joo, J. S., Abrahão, M., Ribeiro, J. C., Cervantes, O., & Sercarz, J. A. (2011). Update on laser photochemotherapy: An alternative for cancer treatment. Anti-Cancer Agents in Medicinal Chemistry, 11(8), 772-779.

Update on laser photochemotherapy : An alternative for cancer treatment. / Paiva, Marcos B.; Joo, Jayne S; Abrahão, Marcio; Ribeiro, Joao Carlos; Cervantes, Onivaldo; Sercarz, Joel A.

In: Anti-Cancer Agents in Medicinal Chemistry, Vol. 11, No. 8, 10.2011, p. 772-779.

Research output: Contribution to journalReview article

Paiva, MB, Joo, JS, Abrahão, M, Ribeiro, JC, Cervantes, O & Sercarz, JA 2011, 'Update on laser photochemotherapy: An alternative for cancer treatment', Anti-Cancer Agents in Medicinal Chemistry, vol. 11, no. 8, pp. 772-779.
Paiva MB, Joo JS, Abrahão M, Ribeiro JC, Cervantes O, Sercarz JA. Update on laser photochemotherapy: An alternative for cancer treatment. Anti-Cancer Agents in Medicinal Chemistry. 2011 Oct;11(8):772-779.
Paiva, Marcos B. ; Joo, Jayne S ; Abrahão, Marcio ; Ribeiro, Joao Carlos ; Cervantes, Onivaldo ; Sercarz, Joel A. / Update on laser photochemotherapy : An alternative for cancer treatment. In: Anti-Cancer Agents in Medicinal Chemistry. 2011 ; Vol. 11, No. 8. pp. 772-779.
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