Update on alcoholic hepatitis

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Alcoholic liver disease is one of the most prevalent liver diseases worldwide, and a major cause of morbidity and mortality. Alcoholic hepatitis is a severe form of liver injury in patients with alcohol abuse, can present as an acute on chronic liver failure associated with a rapid decline in liver synthetic function, and consequent increase in mortality. Despite therapy, about 30%-50% of patients with severe alcoholic hepatitis eventually die. The pathogenic pathways that lead to the development of alcoholic hepatitis are complex and involve oxidative stress, gut dysbiosis, and dysregulation of the innate and adaptive immune system with injury to the parenchymal cells and activation of hepatic stellate cells. As accepted treatment approaches are currently limited, a better understanding of the pathophysiology would be required to generate new approaches that improve outcomes. This review focuses on recent advances in the diagnosis, pathogenesis of alcoholic hepatitis and novel treatment strategies.

Original languageEnglish (US)
Pages (from-to)2978-2986
Number of pages9
JournalBiomolecules
Volume5
Issue number4
DOIs
StatePublished - Nov 2 2015

Fingerprint

Alcoholic Hepatitis
Liver
Dysbiosis
Hepatic Stellate Cells
Alcoholic Liver Diseases
Mortality
Wounds and Injuries
Oxidative stress
Alcoholism
Immune system
Liver Diseases
Immune System
Oxidative Stress
Therapeutics
Morbidity
Chemical activation
Alcohols

Keywords

  • Alcoholic liver injury
  • IL22
  • Oxidative stress
  • Steatohepatitis
  • TNFα

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry
  • Molecular Biology

Cite this

Update on alcoholic hepatitis. / Torok, Natalia J.

In: Biomolecules, Vol. 5, No. 4, 02.11.2015, p. 2978-2986.

Research output: Contribution to journalReview article

Torok, Natalia J. / Update on alcoholic hepatitis. In: Biomolecules. 2015 ; Vol. 5, No. 4. pp. 2978-2986.
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