Unraveling the Fanconi anemia-DNA repair connection

Larry H. Thompson

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

How the Fanconi anemia chromosome stability pathway functions to cope with interstrand crosslinks and other DNA lesions has been elusive. The identification of two new Fanconi anemia-associated proteins with helicase motifs, FANCM and BRIP1 (also called FANCJ or BACH1), implicates the FANC nuclear core complex in recognizing or processing damaged DNA and the BRIP1 helicase as acting independently of this complex.

Original languageEnglish (US)
Pages (from-to)921-922
Number of pages2
JournalNature Genetics
Volume37
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

Fanconi Anemia Complementation Group Proteins
DNA Helicases
Fanconi Anemia
Chromosomal Instability
DNA Repair
DNA

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Unraveling the Fanconi anemia-DNA repair connection. / Thompson, Larry H.

In: Nature Genetics, Vol. 37, No. 9, 09.2005, p. 921-922.

Research output: Contribution to journalArticle

Thompson, Larry H. / Unraveling the Fanconi anemia-DNA repair connection. In: Nature Genetics. 2005 ; Vol. 37, No. 9. pp. 921-922.
@article{e8e064e788cd4cd8afa1cb7bfade5907,
title = "Unraveling the Fanconi anemia-DNA repair connection",
abstract = "How the Fanconi anemia chromosome stability pathway functions to cope with interstrand crosslinks and other DNA lesions has been elusive. The identification of two new Fanconi anemia-associated proteins with helicase motifs, FANCM and BRIP1 (also called FANCJ or BACH1), implicates the FANC nuclear core complex in recognizing or processing damaged DNA and the BRIP1 helicase as acting independently of this complex.",
author = "Thompson, {Larry H.}",
year = "2005",
month = "9",
doi = "10.1038/ng0905-921",
language = "English (US)",
volume = "37",
pages = "921--922",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Unraveling the Fanconi anemia-DNA repair connection

AU - Thompson, Larry H.

PY - 2005/9

Y1 - 2005/9

N2 - How the Fanconi anemia chromosome stability pathway functions to cope with interstrand crosslinks and other DNA lesions has been elusive. The identification of two new Fanconi anemia-associated proteins with helicase motifs, FANCM and BRIP1 (also called FANCJ or BACH1), implicates the FANC nuclear core complex in recognizing or processing damaged DNA and the BRIP1 helicase as acting independently of this complex.

AB - How the Fanconi anemia chromosome stability pathway functions to cope with interstrand crosslinks and other DNA lesions has been elusive. The identification of two new Fanconi anemia-associated proteins with helicase motifs, FANCM and BRIP1 (also called FANCJ or BACH1), implicates the FANC nuclear core complex in recognizing or processing damaged DNA and the BRIP1 helicase as acting independently of this complex.

UR - http://www.scopus.com/inward/record.url?scp=25144492769&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25144492769&partnerID=8YFLogxK

U2 - 10.1038/ng0905-921

DO - 10.1038/ng0905-921

M3 - Article

C2 - 16132046

AN - SCOPUS:25144492769

VL - 37

SP - 921

EP - 922

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 9

ER -