Unraveling lipid metabolism with microarrays: effects of arachidonate and docosahexaenoate acid on murine hepatic and hippocampal gene expression.

Alvin Berger, David M. Mutch, J. Bruce German, Matthew Alan Roberts

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The functions, actions, and regulation of polyunsaturated fatty acids (PUFAs) are beginning to be unraveled. Mice were fed diets rich in either arachidonic acid, docosahexaenoic acid, or both. Liver and hippocampus tissue were then analyzed through a combined gene expression-, lipid-, and behavioral- profiling strategy. Novel hippocampal PUFA-molecular targets suggest that PUFA transcriptionally regulated genes with roles in appetite and learning.

Original languageEnglish (US)
JournalGenome Biology
Volume3
Issue number7
StatePublished - May 23 2002
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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