Unpacking Memory Processes: Using the Attribute Model to Design Optimal Memory Tests for Rodent Models. Using the Attribute Model to Design Optimal Memory Tests for Rodent Models

Michael R. Hunsaker

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

An important consideration in the study of mouse models of any genetic disease is how well the behavior of the mouse serves to actually model the behaviors present in the clinical population being modeled. In order to optimally address this concern is to explicitly develop a behavioral endophenotype of the mouse model in which the mouse is explicitly tested using tasks rigorously designed to explicitly test the cognitive domains affected in the clinical population. To achieve this goal, it is important not only to apply standard behavioral tasks to mouse models of genetic disorders, but also to directly evaluate brain function across all cognitive domains. Furthermore, it is critical for behavioral genetics laboratories to interact with clinical research laboratories to develop comprehensive behavioral endophenotypes for the disorder being modeled. The strength of behavioral genetics and the mouse models is the ability to apply behavioral paradigms known to be subserved by known anatomical loci not only to determine the behavioral phenotype of the model, but also to elucidate candidate brain regions affected by the mutation. When research into mouse models of genetic disorders emphasizes patterns of mnemonic strengths and weaknesses across domains (i.e., the behavioral endophenotype), the results will not only directly model the disorder being studied, but also serve both as risk prodrome for disease onset or progression and as outcome measures that can be applied by the clinic in interventional studies.

Original languageEnglish (US)
Title of host publicationIdentification of Neural Markers Accompanying Memory
PublisherElsevier Inc.
Pages95-111
Number of pages17
ISBN (Print)9780124081390
DOIs
StatePublished - Nov 2013

Keywords

  • Attribute model
  • Endophenotypes
  • Experimental design
  • Learning and memory
  • Mouse models

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Unpacking Memory Processes: Using the Attribute Model to Design Optimal Memory Tests for Rodent Models. Using the Attribute Model to Design Optimal Memory Tests for Rodent Models'. Together they form a unique fingerprint.

  • Cite this