Unmasking the borderline coarctation: The utility of isoproterenol in the paediatric cardiac catheterisation laboratory

Neil D. Patel, Patrick M. Sullivan, Cheryl M. Takao, Sarah Badran, Joseph Ahdoot, Frank Ing

Research output: Contribution to journalArticle

Abstract

Background One indication for intervention in coarctation of the aorta is a peak-to-peak gradient >20 mmHg. Gradients may be masked in patients under general anaesthesia and may be higher during exercise. Isoproterenol was given during cardiac catheterisation to simulate a more active physiologic state.Objectives We aimed to describe the haemodynamic effects of isoproterenol in patients with coarctation and the impact of intervention on the elicited gradients.Methods A retrospective study was performed on two-ventricle patients who underwent cardiac catheterisation for coarctation with isoproterenol testing.Results 25 patients received isoproterenol before and after intervention. With isoproterenol, the mean diastolic (p=0.0015) and mean arterial (p=0.0065) blood pressures proximal to the coarctation decreased significantly. The mean systolic, diastolic, and mean arterial blood pressures distal to the coarctation decreased significantly (p<0.0001). In patients with a baseline gradient â

Original languageEnglish (US)
Pages (from-to)804-810
Number of pages7
JournalCardiology in the Young
Volume28
Issue number6
DOIs
StatePublished - Jun 1 2018

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Cardiac Catheterization
Isoproterenol
Pediatrics
Arterial Pressure
Aortic Coarctation
General Anesthesia
Retrospective Studies
Hemodynamics
Exercise
Blood Pressure

Keywords

  • Coarctation
  • exercise testing
  • isoproterenol
  • stent

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

Unmasking the borderline coarctation : The utility of isoproterenol in the paediatric cardiac catheterisation laboratory. / Patel, Neil D.; Sullivan, Patrick M.; Takao, Cheryl M.; Badran, Sarah; Ahdoot, Joseph; Ing, Frank.

In: Cardiology in the Young, Vol. 28, No. 6, 01.06.2018, p. 804-810.

Research output: Contribution to journalArticle

Patel, Neil D. ; Sullivan, Patrick M. ; Takao, Cheryl M. ; Badran, Sarah ; Ahdoot, Joseph ; Ing, Frank. / Unmasking the borderline coarctation : The utility of isoproterenol in the paediatric cardiac catheterisation laboratory. In: Cardiology in the Young. 2018 ; Vol. 28, No. 6. pp. 804-810.
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