Unlike bone, cartilage regeneration remains elusive

Daniel J. Huey, Jerry C. Hu, Kyriacos A. Athanasiou

Research output: Contribution to journalArticle

392 Citations (Scopus)

Abstract

Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue. We also discuss technologies that can address the hurdles of engineering a tissue possessing mechanical properties that are unmatched in human-made materials and functioning in environments unfavorable to neotissue growth.

Original languageEnglish (US)
Pages (from-to)917-921
Number of pages5
JournalScience
Volume338
Issue number6109
DOIs
StatePublished - Nov 16 2012

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Cartilage
Regeneration
Bone and Bones
Bone Regeneration
Articular Cartilage
Tissue Engineering
Technology
Growth

ASJC Scopus subject areas

  • General

Cite this

Huey, D. J., Hu, J. C., & Athanasiou, K. A. (2012). Unlike bone, cartilage regeneration remains elusive. Science, 338(6109), 917-921. https://doi.org/10.1126/science.1222454

Unlike bone, cartilage regeneration remains elusive. / Huey, Daniel J.; Hu, Jerry C.; Athanasiou, Kyriacos A.

In: Science, Vol. 338, No. 6109, 16.11.2012, p. 917-921.

Research output: Contribution to journalArticle

Huey, DJ, Hu, JC & Athanasiou, KA 2012, 'Unlike bone, cartilage regeneration remains elusive', Science, vol. 338, no. 6109, pp. 917-921. https://doi.org/10.1126/science.1222454
Huey DJ, Hu JC, Athanasiou KA. Unlike bone, cartilage regeneration remains elusive. Science. 2012 Nov 16;338(6109):917-921. https://doi.org/10.1126/science.1222454
Huey, Daniel J. ; Hu, Jerry C. ; Athanasiou, Kyriacos A. / Unlike bone, cartilage regeneration remains elusive. In: Science. 2012 ; Vol. 338, No. 6109. pp. 917-921.
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