Unlike bone, cartilage regeneration remains elusive

Daniel J. Huey, Jerry C. Hu, Kyriacos A. Athanasiou

Research output: Contribution to journalArticle

501 Scopus citations


Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue. We also discuss technologies that can address the hurdles of engineering a tissue possessing mechanical properties that are unmatched in human-made materials and functioning in environments unfavorable to neotissue growth.

Original languageEnglish (US)
Pages (from-to)917-921
Number of pages5
Issue number6109
StatePublished - Nov 16 2012

ASJC Scopus subject areas

  • General

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    Huey, D. J., Hu, J. C., & Athanasiou, K. A. (2012). Unlike bone, cartilage regeneration remains elusive. Science, 338(6109), 917-921. https://doi.org/10.1126/science.1222454