Abstract
We present a 17-year-old boy who developed a generalized urticarial eruption, malar rash, fever, and arthralgia within one week of initiating minocycline therapy for acne. His workup showed positive anti-nuclear and anti-histone antibodies. His symptoms quickly resolved after discontinuing minocycline and starting oral prednisone. We believe the constellation of his symptoms, laboratory findings, and temporal association of minocycline initiation was suggestive of minocycline-induced lupus. Unique to this case is that his urticarial presentation was so striking that it could have been initially regarded as drug induced urticaria without considering drug-induced lupus. Since minocycline is so widely prescribed for acne among the dermatology community, we believe that it is important for dermatologists to be aware of this alternative clinical presentation of minocycline-induced lupus.
| Original language | English (US) |
|---|---|
| Journal | Dermatology Online Journal |
| Volume | 23 |
| Issue number | 8 |
| State | Published - 2017 |
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Keywords
- Anti-histone
- Drug induced lupus
- Drug reaction
- Lupus
- Minocycline
- Urticaria
ASJC Scopus subject areas
- Dermatology
Cite this
Unique urticarial presentation of minocycline-induced lupus erythematosus. / Clark, Ashley K.; Shi, Vivian Y.; Sivamani, Raja K.
In: Dermatology Online Journal, Vol. 23, No. 8, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unique urticarial presentation of minocycline-induced lupus erythematosus
AU - Clark, Ashley K.
AU - Shi, Vivian Y.
AU - Sivamani, Raja K
PY - 2017
Y1 - 2017
N2 - We present a 17-year-old boy who developed a generalized urticarial eruption, malar rash, fever, and arthralgia within one week of initiating minocycline therapy for acne. His workup showed positive anti-nuclear and anti-histone antibodies. His symptoms quickly resolved after discontinuing minocycline and starting oral prednisone. We believe the constellation of his symptoms, laboratory findings, and temporal association of minocycline initiation was suggestive of minocycline-induced lupus. Unique to this case is that his urticarial presentation was so striking that it could have been initially regarded as drug induced urticaria without considering drug-induced lupus. Since minocycline is so widely prescribed for acne among the dermatology community, we believe that it is important for dermatologists to be aware of this alternative clinical presentation of minocycline-induced lupus.
AB - We present a 17-year-old boy who developed a generalized urticarial eruption, malar rash, fever, and arthralgia within one week of initiating minocycline therapy for acne. His workup showed positive anti-nuclear and anti-histone antibodies. His symptoms quickly resolved after discontinuing minocycline and starting oral prednisone. We believe the constellation of his symptoms, laboratory findings, and temporal association of minocycline initiation was suggestive of minocycline-induced lupus. Unique to this case is that his urticarial presentation was so striking that it could have been initially regarded as drug induced urticaria without considering drug-induced lupus. Since minocycline is so widely prescribed for acne among the dermatology community, we believe that it is important for dermatologists to be aware of this alternative clinical presentation of minocycline-induced lupus.
KW - Anti-histone
KW - Drug induced lupus
KW - Drug reaction
KW - Lupus
KW - Minocycline
KW - Urticaria
UR - http://www.scopus.com/inward/record.url?scp=85029509351&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029509351&partnerID=8YFLogxK
M3 - Article
C2 - 29469742
AN - SCOPUS:85029509351
VL - 23
JO - Dermatology Online Journal
JF - Dermatology Online Journal
SN - 1087-2108
IS - 8
ER -