Unique clinical features and prognostic significance of the translocation (6;11) in acute leukemia

Jeanna L Welborn, Helen M. Jenks, A. Hagemeijer

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A translocation (6;11)(q26-27;q23) was detected in four male patients diagnosed with acute T-cell lymphoblastic leukemia and acute myelomonocytic and monocytic leukemias. This acquired reciprocal translocation appears to be associated with acute leukemias in young men who present clinically with localized infection, and a moderate leukocytosis. There was a poor response to antileukemic chemotherapy and a short overall survival. Aggressive treatment strategies should be considered in the treatment of these high-risk leukemias.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume65
Issue number2
DOIs
StatePublished - 1993

Fingerprint

Leukemia
Leukemia, Myelomonocytic, Acute
Leukemia, Monocytic, Acute
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Leukocytosis
Drug Therapy
Survival
Therapeutics
Infection

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Unique clinical features and prognostic significance of the translocation (6;11) in acute leukemia. / Welborn, Jeanna L; Jenks, Helen M.; Hagemeijer, A.

In: Cancer Genetics and Cytogenetics, Vol. 65, No. 2, 1993, p. 125-129.

Research output: Contribution to journalArticle

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