Unilateral hypoxic pulmonary vasoconstriction in the dog, pony and miniature swine

Ann R. Elliott; Eugene Steffey; Kathleen A. Jarvis; Bryan E. Marshall

doi:10.1016/0034-5687(91)90074-S

Unilateral hypoxic pulmonary vasoconstriction in the dog, pony and miniature swine

Ann R. Elliott, Eugene Steffey, Kathleen A. Jarvis, Bryan E. Marshall

California Animal Health & Food Safety Lab

Research output: Contribution to journal › Article

34 Scopus citations

Abstract

The hypoxic pulmonary vasoconstrictor response to unilateral hypoxia was analyzed in pentobarbital anesthetized dogs (n = 5), miniature swine (n = 5), and ponies (n = 5). The left and right lungs (LL, RL) were separately ventilated with the LL exposed to inspired oxygen concentrations (CI_O₂) of 100%, 12%, 8% or 4%, while the RL always received a CI_O₂ = 100%. Pulmonary blood flow diversion was measured using 15 μm radioactive microspheres. LL PA_O₂, and percent pulmonary blood flow diversion (%FD) were calculated at each Ci_O₂. At Ci_O₂ of 4% there were significant differences (P ≥ 0.05) between the %FD responses of each species (mean ± S.E.): the %FD_swine (95.1 ± 1.3) > %FD_pony (76.0 ± 4.6) > %FD_dog (50.1 ± 9.4). For all species, the %FD was inversely related to the level of regional hypoxia, but there were marked species differences in the magnitude and sensitivity of hypoxic pulmonary vasoconstriction with the swine being the strongest responder, the pony intermediate, and the dog the weakest responder.

Original language	English (US)
Pages (from-to)	355-369
Number of pages	15
Journal	Respiration Physiology
Volume	85
Issue number	3
DOIs	https://doi.org/10.1016/0034-5687(91)90074-S
State	Published - Jan 1 1991

Keywords

blood flow, pulmonary, hypoxic vasoconstriction
Hypoxia, pulmonary vasoconstriction
Mammals, dog, pony, swine

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

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Elliott, A. R., Steffey, E., Jarvis, K. A., & Marshall, B. E. (1991). Unilateral hypoxic pulmonary vasoconstriction in the dog, pony and miniature swine. Respiration Physiology, 85(3), 355-369. https://doi.org/10.1016/0034-5687(91)90074-S

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