Unilateral and bilateral expression of a quantitative trait: Asymmetry and symmetry in coronal craniosynostosis

Yann Heuzé, Neus Martínez-Abadías, Jennifer M. Stella, Craig W Senders, Simeon Boyd, Lun Jou Lo, Joan T. Richtsmeier

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Bilateral symmetry in vertebrates is imperfect and mild asymmetries are found in normal growth and development. However, abnormal development is often characterized by strong asymmetries. Coronal craniosynostosis, defined here as consisting of premature suture closure and a characteristic skull shape, is a complex trait. The premature fusion of the coronal suture can occur unilaterally associated with skull asymmetry (anterior plagiocephaly) or bilaterally associated with a symmetric but brachycephalic skull. We investigated the relationship between coronal craniosynostosis and skull bilateral symmetry. Three-dimensional landmark coordinates were recorded on preoperative computed tomography images of children diagnosed with coronal nonsyndromic craniosynostosis (N = 40) and that of unaffected individuals (N = 20) and analyzed by geometric morphometrics. Our results showed that the fusion pattern of the coronal suture is similar across individuals and types of coronal craniosynostosis. Shape analysis showed that skulls of bilateral coronal craniosynostosis (BCS) and unaffected individuals display low degrees of asymmetry, whereas right and left unilateral coronal craniosynostosis (UCS) skulls are asymmetric and mirror images of one another. When premature fusion of the coronal suture (without taking into account cranial dysmorphology) is scored as a qualitative trait, the expected relationship between trait frequency and trait unilateral expression (i.e. negative correlation) is confirmed. Overall, we interpret our results as evidence that the same biological processes operate on the two sides in BCS skulls and on the affected side in UCS skulls, and that coronal craniosynostosis is a quantitative trait exhibiting a phenotypic continuum with BCS displaying more intense shape changes than UCS.

Original languageEnglish (US)
Pages (from-to)109-122
Number of pages14
JournalJournal of Experimental Zoology Part B: Molecular and Developmental Evolution
Volume318
Issue number2
DOIs
StatePublished - Mar 2012

Fingerprint

Craniosynostoses
skull
quantitative traits
symmetry
asymmetry
Skull
sutures
Sutures
shape analysis
Plagiocephaly
abnormal development
computed tomography
growth and development
Biological Phenomena
biological processes
tomography
vertebrate
vertebrates
Growth and Development
Vertebrates

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Medicine
  • Genetics
  • Developmental Biology

Cite this

Unilateral and bilateral expression of a quantitative trait : Asymmetry and symmetry in coronal craniosynostosis. / Heuzé, Yann; Martínez-Abadías, Neus; Stella, Jennifer M.; Senders, Craig W; Boyd, Simeon; Lo, Lun Jou; Richtsmeier, Joan T.

In: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Vol. 318, No. 2, 03.2012, p. 109-122.

Research output: Contribution to journalArticle

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