Abstract
The susceptibility of 12 strains of Coccidioides immitis to amphotericin B (amB) was studied in vitro and in vivo. The minimal inhibitory concentration (MIC) of the mycelial phase of these strains was 0.078 to 0.16 μg/ml after 3 days of incubation, but by 15 days all strains were inhibited by 2.5 μg/ml. Mice infected intraperitoneally with these strains were successfully treated with 0.5 mg of amB per kg per day. These strains included several studied by others and which reportedly varied widely in susceptibility (MIC from 0.24 to 24.01 μg/ml) to amB. Four of these strains representing this putative broad range of susceptibility were used to infect mice intranasally. Regardless of infecting strain, mice were successfully treated with 0.38, 0.75, and 1.5 mg/kg, but 0.19 mg/kg was only partially effective. Thus, in vivo as well as in vitro there was a uniform response of C. immitis strains to amB.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1049-1055 |
| Number of pages | 7 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 11 |
| Issue number | 6 |
| State | Published - 1977 |
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ASJC Scopus subject areas
- Pharmacology (medical)
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Uniform susceptibility of various strains of Coccidioides immitis to amphotericin B. / Collins, M. S.; Pappagianis, Demosthenes.
In: Antimicrobial Agents and Chemotherapy, Vol. 11, No. 6, 1977, p. 1049-1055.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Uniform susceptibility of various strains of Coccidioides immitis to amphotericin B
AU - Collins, M. S.
AU - Pappagianis, Demosthenes
PY - 1977
Y1 - 1977
N2 - The susceptibility of 12 strains of Coccidioides immitis to amphotericin B (amB) was studied in vitro and in vivo. The minimal inhibitory concentration (MIC) of the mycelial phase of these strains was 0.078 to 0.16 μg/ml after 3 days of incubation, but by 15 days all strains were inhibited by 2.5 μg/ml. Mice infected intraperitoneally with these strains were successfully treated with 0.5 mg of amB per kg per day. These strains included several studied by others and which reportedly varied widely in susceptibility (MIC from 0.24 to 24.01 μg/ml) to amB. Four of these strains representing this putative broad range of susceptibility were used to infect mice intranasally. Regardless of infecting strain, mice were successfully treated with 0.38, 0.75, and 1.5 mg/kg, but 0.19 mg/kg was only partially effective. Thus, in vivo as well as in vitro there was a uniform response of C. immitis strains to amB.
AB - The susceptibility of 12 strains of Coccidioides immitis to amphotericin B (amB) was studied in vitro and in vivo. The minimal inhibitory concentration (MIC) of the mycelial phase of these strains was 0.078 to 0.16 μg/ml after 3 days of incubation, but by 15 days all strains were inhibited by 2.5 μg/ml. Mice infected intraperitoneally with these strains were successfully treated with 0.5 mg of amB per kg per day. These strains included several studied by others and which reportedly varied widely in susceptibility (MIC from 0.24 to 24.01 μg/ml) to amB. Four of these strains representing this putative broad range of susceptibility were used to infect mice intranasally. Regardless of infecting strain, mice were successfully treated with 0.38, 0.75, and 1.5 mg/kg, but 0.19 mg/kg was only partially effective. Thus, in vivo as well as in vitro there was a uniform response of C. immitis strains to amB.
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M3 - Article
C2 - 879751
AN - SCOPUS:0017704491
VL - 11
SP - 1049
EP - 1055
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 6
ER -