Unexpected Role of CD8 T Cells in Accelerated Clearance of Salmonella enterica Serovar Typhimurium from H-2 Congenic mice

Jasmine C. Labuda, Claire E. Depew, Oanh H. Pham, Joseph M. Benoun, Nora A. Ramirez, Stephen J. McSorley

Research output: Contribution to journalArticle

Abstract

Salmonella infection can cause gastroenteritis in healthy individuals or a serious, systemic infection in immunocompromised patients and has a global impact. CD4 Th1 cells represent the main lymphocyte population that participates in bacterial clearance during both primary and secondary infections in mice of the H-2b haplotype. Previous studies have used congenic mice to examine the function of major histocompatibility complex (MHC) molecules in elimination of this pathogen from the host. In this study, we further characterized the ability of H-2b, H-2k, and H-2u molecules to influence adaptive immunity to Salmonella in MHC congenic mice. By depleting different cell populations during infection, we unexpectedly found that CD8 T cells, in addition to CD4 T cells, play a major role in accelerated clearance of bacteria from H-2k congenic hosts. Our data suggest that CD8 T cells accelerate clearance in some MHC congenic mouse strains and could therefore represent an unexpected contributor to the protective efficacy of Salmonella vaccines outside the typical studies in C57BL/6 mice.

Original languageEnglish (US)
JournalInfection and immunity
Volume87
Issue number11
DOIs
StatePublished - Nov 1 2019

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Congenic Mice
Salmonella enterica
Major Histocompatibility Complex
T-Lymphocytes
Salmonella Vaccines
Th1 Cells
Salmonella Infections
Gastroenteritis
Immunocompromised Host
Adaptive Immunity
Infection
Coinfection
Inbred C57BL Mouse
Salmonella
Haplotypes
Population
Lymphocytes
Bacteria
Serogroup

Keywords

  • CD4 T cells
  • CD8 T cells
  • MHC
  • Salmonella

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Unexpected Role of CD8 T Cells in Accelerated Clearance of Salmonella enterica Serovar Typhimurium from H-2 Congenic mice. / Labuda, Jasmine C.; Depew, Claire E.; Pham, Oanh H.; Benoun, Joseph M.; Ramirez, Nora A.; McSorley, Stephen J.

In: Infection and immunity, Vol. 87, No. 11, 01.11.2019.

Research output: Contribution to journalArticle

Labuda, Jasmine C. ; Depew, Claire E. ; Pham, Oanh H. ; Benoun, Joseph M. ; Ramirez, Nora A. ; McSorley, Stephen J. / Unexpected Role of CD8 T Cells in Accelerated Clearance of Salmonella enterica Serovar Typhimurium from H-2 Congenic mice. In: Infection and immunity. 2019 ; Vol. 87, No. 11.
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