Undifferentiated carcinoma of unknown origin in the lumbar spine of a dog

Jiyoung Park, Seong Mok Jeong, Ho Jung Choi, Kun Ho Song, Kyoung Won Seo

Research output: Contribution to journalArticle

Abstract

An 11-year-old Yorkshire Terrier dog presented with progressive ataxia and paraparesis of 1 month duration. The abnormality was localized to the T13-L2 segment by neurologic examination and CT. MRI showed a space-occupying lesion compressing the spinal cord and adjacent osteolysis of the L1 vertebra. A diagnosis of poorly differentiated carcinoma with high malignancy was reached by histopathology of the biopsy samples. Metronomic chemotherapy was applied, but the patient was euthanized at 133 days after first presentation. Samples of the lumbar mass, pulmonary nodules, and lymph nodes were obtained during necropsy and evaluated with histopathology and immunohistochemistry (IHC). Undifferentiated carcinoma suspicious of transitional cell carcinoma was confirmed, but the exact origin of the tumor was undetermined. This is the first case report of an extradural primary carcinoma of unknown primary in the canine spinal cord and paravertebral region.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalPakistan Veterinary Journal
Volume35
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

lumbar spine
carcinoma
Spine
Dogs
Carcinoma
dogs
Spinal Cord
spinal cord
histopathology
Paraparesis
Osteolysis
Transitional Cell Carcinoma
Neurologic Examination
Ataxia
Canidae
Neoplasms
Lymph Nodes
vertebrae
Immunohistochemistry
lesions (animal)

Keywords

  • Carcinoma of unknown primary
  • Dog
  • Metastasis
  • Spinal cord neoplasia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Park, J., Jeong, S. M., Choi, H. J., Song, K. H., & Seo, K. W. (2015). Undifferentiated carcinoma of unknown origin in the lumbar spine of a dog. Pakistan Veterinary Journal, 35(1), 116-118.

Undifferentiated carcinoma of unknown origin in the lumbar spine of a dog. / Park, Jiyoung; Jeong, Seong Mok; Choi, Ho Jung; Song, Kun Ho; Seo, Kyoung Won.

In: Pakistan Veterinary Journal, Vol. 35, No. 1, 01.01.2015, p. 116-118.

Research output: Contribution to journalArticle

Park, J, Jeong, SM, Choi, HJ, Song, KH & Seo, KW 2015, 'Undifferentiated carcinoma of unknown origin in the lumbar spine of a dog', Pakistan Veterinary Journal, vol. 35, no. 1, pp. 116-118.
Park, Jiyoung ; Jeong, Seong Mok ; Choi, Ho Jung ; Song, Kun Ho ; Seo, Kyoung Won. / Undifferentiated carcinoma of unknown origin in the lumbar spine of a dog. In: Pakistan Veterinary Journal. 2015 ; Vol. 35, No. 1. pp. 116-118.
@article{49103ae70e1042f0ba7da82ce2c40ccc,
title = "Undifferentiated carcinoma of unknown origin in the lumbar spine of a dog",
abstract = "An 11-year-old Yorkshire Terrier dog presented with progressive ataxia and paraparesis of 1 month duration. The abnormality was localized to the T13-L2 segment by neurologic examination and CT. MRI showed a space-occupying lesion compressing the spinal cord and adjacent osteolysis of the L1 vertebra. A diagnosis of poorly differentiated carcinoma with high malignancy was reached by histopathology of the biopsy samples. Metronomic chemotherapy was applied, but the patient was euthanized at 133 days after first presentation. Samples of the lumbar mass, pulmonary nodules, and lymph nodes were obtained during necropsy and evaluated with histopathology and immunohistochemistry (IHC). Undifferentiated carcinoma suspicious of transitional cell carcinoma was confirmed, but the exact origin of the tumor was undetermined. This is the first case report of an extradural primary carcinoma of unknown primary in the canine spinal cord and paravertebral region.",
keywords = "Carcinoma of unknown primary, Dog, Metastasis, Spinal cord neoplasia",
author = "Jiyoung Park and Jeong, {Seong Mok} and Choi, {Ho Jung} and Song, {Kun Ho} and Seo, {Kyoung Won}",
year = "2015",
month = "1",
day = "1",
language = "English (US)",
volume = "35",
pages = "116--118",
journal = "Pakistan Veterinary Journal",
issn = "0253-8318",
publisher = "Faculty Of Veterinary Science, University Of Agriculture",
number = "1",

}

TY - JOUR

T1 - Undifferentiated carcinoma of unknown origin in the lumbar spine of a dog

AU - Park, Jiyoung

AU - Jeong, Seong Mok

AU - Choi, Ho Jung

AU - Song, Kun Ho

AU - Seo, Kyoung Won

PY - 2015/1/1

Y1 - 2015/1/1

N2 - An 11-year-old Yorkshire Terrier dog presented with progressive ataxia and paraparesis of 1 month duration. The abnormality was localized to the T13-L2 segment by neurologic examination and CT. MRI showed a space-occupying lesion compressing the spinal cord and adjacent osteolysis of the L1 vertebra. A diagnosis of poorly differentiated carcinoma with high malignancy was reached by histopathology of the biopsy samples. Metronomic chemotherapy was applied, but the patient was euthanized at 133 days after first presentation. Samples of the lumbar mass, pulmonary nodules, and lymph nodes were obtained during necropsy and evaluated with histopathology and immunohistochemistry (IHC). Undifferentiated carcinoma suspicious of transitional cell carcinoma was confirmed, but the exact origin of the tumor was undetermined. This is the first case report of an extradural primary carcinoma of unknown primary in the canine spinal cord and paravertebral region.

AB - An 11-year-old Yorkshire Terrier dog presented with progressive ataxia and paraparesis of 1 month duration. The abnormality was localized to the T13-L2 segment by neurologic examination and CT. MRI showed a space-occupying lesion compressing the spinal cord and adjacent osteolysis of the L1 vertebra. A diagnosis of poorly differentiated carcinoma with high malignancy was reached by histopathology of the biopsy samples. Metronomic chemotherapy was applied, but the patient was euthanized at 133 days after first presentation. Samples of the lumbar mass, pulmonary nodules, and lymph nodes were obtained during necropsy and evaluated with histopathology and immunohistochemistry (IHC). Undifferentiated carcinoma suspicious of transitional cell carcinoma was confirmed, but the exact origin of the tumor was undetermined. This is the first case report of an extradural primary carcinoma of unknown primary in the canine spinal cord and paravertebral region.

KW - Carcinoma of unknown primary

KW - Dog

KW - Metastasis

KW - Spinal cord neoplasia

UR - http://www.scopus.com/inward/record.url?scp=84920770486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920770486&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84920770486

VL - 35

SP - 116

EP - 118

JO - Pakistan Veterinary Journal

JF - Pakistan Veterinary Journal

SN - 0253-8318

IS - 1

ER -