Abstract
An 11-year-old Yorkshire Terrier dog presented with progressive ataxia and paraparesis of 1 month duration. The abnormality was localized to the T13-L2 segment by neurologic examination and CT. MRI showed a space-occupying lesion compressing the spinal cord and adjacent osteolysis of the L1 vertebra. A diagnosis of poorly differentiated carcinoma with high malignancy was reached by histopathology of the biopsy samples. Metronomic chemotherapy was applied, but the patient was euthanized at 133 days after first presentation. Samples of the lumbar mass, pulmonary nodules, and lymph nodes were obtained during necropsy and evaluated with histopathology and immunohistochemistry (IHC). Undifferentiated carcinoma suspicious of transitional cell carcinoma was confirmed, but the exact origin of the tumor was undetermined. This is the first case report of an extradural primary carcinoma of unknown primary in the canine spinal cord and paravertebral region.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 116-118 |
| Number of pages | 3 |
| Journal | Pakistan Veterinary Journal |
| Volume | 35 |
| Issue number | 1 |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
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Keywords
- Carcinoma of unknown primary
- Dog
- Metastasis
- Spinal cord neoplasia
ASJC Scopus subject areas
- veterinary(all)
Cite this
Undifferentiated carcinoma of unknown origin in the lumbar spine of a dog. / Park, Jiyoung; Jeong, Seong Mok; Choi, Ho Jung; Song, Kun Ho; Seo, Kyoung Won.
In: Pakistan Veterinary Journal, Vol. 35, No. 1, 01.01.2015, p. 116-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Undifferentiated carcinoma of unknown origin in the lumbar spine of a dog
AU - Park, Jiyoung
AU - Jeong, Seong Mok
AU - Choi, Ho Jung
AU - Song, Kun Ho
AU - Seo, Kyoung Won
PY - 2015/1/1
Y1 - 2015/1/1
N2 - An 11-year-old Yorkshire Terrier dog presented with progressive ataxia and paraparesis of 1 month duration. The abnormality was localized to the T13-L2 segment by neurologic examination and CT. MRI showed a space-occupying lesion compressing the spinal cord and adjacent osteolysis of the L1 vertebra. A diagnosis of poorly differentiated carcinoma with high malignancy was reached by histopathology of the biopsy samples. Metronomic chemotherapy was applied, but the patient was euthanized at 133 days after first presentation. Samples of the lumbar mass, pulmonary nodules, and lymph nodes were obtained during necropsy and evaluated with histopathology and immunohistochemistry (IHC). Undifferentiated carcinoma suspicious of transitional cell carcinoma was confirmed, but the exact origin of the tumor was undetermined. This is the first case report of an extradural primary carcinoma of unknown primary in the canine spinal cord and paravertebral region.
AB - An 11-year-old Yorkshire Terrier dog presented with progressive ataxia and paraparesis of 1 month duration. The abnormality was localized to the T13-L2 segment by neurologic examination and CT. MRI showed a space-occupying lesion compressing the spinal cord and adjacent osteolysis of the L1 vertebra. A diagnosis of poorly differentiated carcinoma with high malignancy was reached by histopathology of the biopsy samples. Metronomic chemotherapy was applied, but the patient was euthanized at 133 days after first presentation. Samples of the lumbar mass, pulmonary nodules, and lymph nodes were obtained during necropsy and evaluated with histopathology and immunohistochemistry (IHC). Undifferentiated carcinoma suspicious of transitional cell carcinoma was confirmed, but the exact origin of the tumor was undetermined. This is the first case report of an extradural primary carcinoma of unknown primary in the canine spinal cord and paravertebral region.
KW - Carcinoma of unknown primary
KW - Dog
KW - Metastasis
KW - Spinal cord neoplasia
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UR - http://www.scopus.com/inward/citedby.url?scp=84920770486&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84920770486
VL - 35
SP - 116
EP - 118
JO - Pakistan Veterinary Journal
JF - Pakistan Veterinary Journal
SN - 0253-8318
IS - 1
ER -