Understanding phosphoinositides: Rare, dynamic, and essential membrane phospholipids

Eamonn J Dickson, Bertil Hille

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell’s life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane–cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalBiochemical Journal
Volume476
Issue number1
DOIs
StatePublished - Jan 7 2019

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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