Understanding laboratory testing for SARS-CoV-2

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1 Scopus citations


The SARS-CoV-2 pandemic has impacted millions of lives worldwide. Molecular assays and serological tests have been approved under EUA (emergency use authorization) by the FDA (food and drug administration), given these unprecedented times. These tests are not only critical for confirming the clinical diagnosis and making therapeutic decisions but also play an important role in the understanding of the epidemiology of the pandemic. There is limited experience with currently available tests and differences may exist among tests even using similar technology. The focus of this review is to improve clinicians’ understanding of SARS-CoV-2 test procedures including their limitations. We discuss the impact of different host and environmental factors on test results.

Original languageEnglish (US)
Article number355
Issue number5
StatePublished - May 2021


  • Antibody testing
  • Nucleic acid amplification test
  • Pandemic
  • Point-of-care test
  • Rapid antigen test
  • RT-PCR
  • SARS-CoV-2
  • Serology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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