Under-grading of <4 cm renal masses on renal biopsy

Catherine R. Harris, Jared M Whitson, Maxwell V. Meng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective To determine whether differences exist in tumour grade between patients who undergo partial nephrectomy (PN) and those who undergo ablation for renal tumours. Patients and Methods Data was obtained using the Surveillance, Epidemiology and End Results database. Patients with solitary renal tumours of <4 cm treated with ablation or PN and with renal cell carcinoma (RCC) histopathology were identified. Tissue diagnosis in the ablation specimens was obtained from biopsy reports, whereas tissue from PN specimens was determined from surgical pathology. Variables analysed included: year of diagnosis, age, sex, race/ethnicity, marital status, population density, education, poverty level, and tumour size. Stacked bar graphs were created to compare the distributions of grade and histology between the groups. Multinomial logistic regression was used to determine factors independently associated with grade. Results In all, 7704 (87.4%) patients underwent PN and 1114 (12.6%) underwent either radiofrequency ablation or cryoablation. The PN patients were younger at diagnosis (59 vs 68 years, P < 0.001), more likely to be married (70% vs 64%, P < 0.001), and had smaller tumours (2.4 vs 2.6 cm, P < 0.001). There were no differences in the distribution of histology between the PN and ablation groups. Tumour grade was significantly lower in tumours treated with ablation. Compared with grade 1 disease, those undergoing ablation were 30% less likely to have grade 2 (P < 0.001), 30% less likely to have grade 3 (P < 0.001), and 92% less likely to have grade 4 disease (P < 0.01) than those having PN. Conclusions There is a strong association between grade and treatment type in patients with small renal masses after controlling for baseline characteristics. As grade is determined by different methods, we think that this shows systematic under-grading in biopsy of small renal masses.

Original languageEnglish (US)
Pages (from-to)794-797
Number of pages4
JournalBJU International
Volume110
Issue number6
DOIs
StatePublished - Sep 2012
Externally publishedYes

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Nephrectomy
Kidney
Biopsy
Neoplasms
Histology
Surgical Pathology
Cryosurgery
Marital Status
Poverty
Population Density
Renal Cell Carcinoma
Epidemiology
Logistic Models
Databases
Education

Keywords

  • ablation
  • Fuhrman grade
  • nephron-sparing surgery
  • renal cell carcinoma
  • renal mass biopsy

ASJC Scopus subject areas

  • Urology

Cite this

Under-grading of <4 cm renal masses on renal biopsy. / Harris, Catherine R.; Whitson, Jared M; Meng, Maxwell V.

In: BJU International, Vol. 110, No. 6, 09.2012, p. 794-797.

Research output: Contribution to journalArticle

Harris, Catherine R. ; Whitson, Jared M ; Meng, Maxwell V. / Under-grading of <4 cm renal masses on renal biopsy. In: BJU International. 2012 ; Vol. 110, No. 6. pp. 794-797.
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abstract = "Objective To determine whether differences exist in tumour grade between patients who undergo partial nephrectomy (PN) and those who undergo ablation for renal tumours. Patients and Methods Data was obtained using the Surveillance, Epidemiology and End Results database. Patients with solitary renal tumours of <4 cm treated with ablation or PN and with renal cell carcinoma (RCC) histopathology were identified. Tissue diagnosis in the ablation specimens was obtained from biopsy reports, whereas tissue from PN specimens was determined from surgical pathology. Variables analysed included: year of diagnosis, age, sex, race/ethnicity, marital status, population density, education, poverty level, and tumour size. Stacked bar graphs were created to compare the distributions of grade and histology between the groups. Multinomial logistic regression was used to determine factors independently associated with grade. Results In all, 7704 (87.4{\%}) patients underwent PN and 1114 (12.6{\%}) underwent either radiofrequency ablation or cryoablation. The PN patients were younger at diagnosis (59 vs 68 years, P < 0.001), more likely to be married (70{\%} vs 64{\%}, P < 0.001), and had smaller tumours (2.4 vs 2.6 cm, P < 0.001). There were no differences in the distribution of histology between the PN and ablation groups. Tumour grade was significantly lower in tumours treated with ablation. Compared with grade 1 disease, those undergoing ablation were 30{\%} less likely to have grade 2 (P < 0.001), 30{\%} less likely to have grade 3 (P < 0.001), and 92{\%} less likely to have grade 4 disease (P < 0.01) than those having PN. Conclusions There is a strong association between grade and treatment type in patients with small renal masses after controlling for baseline characteristics. As grade is determined by different methods, we think that this shows systematic under-grading in biopsy of small renal masses.",
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N2 - Objective To determine whether differences exist in tumour grade between patients who undergo partial nephrectomy (PN) and those who undergo ablation for renal tumours. Patients and Methods Data was obtained using the Surveillance, Epidemiology and End Results database. Patients with solitary renal tumours of <4 cm treated with ablation or PN and with renal cell carcinoma (RCC) histopathology were identified. Tissue diagnosis in the ablation specimens was obtained from biopsy reports, whereas tissue from PN specimens was determined from surgical pathology. Variables analysed included: year of diagnosis, age, sex, race/ethnicity, marital status, population density, education, poverty level, and tumour size. Stacked bar graphs were created to compare the distributions of grade and histology between the groups. Multinomial logistic regression was used to determine factors independently associated with grade. Results In all, 7704 (87.4%) patients underwent PN and 1114 (12.6%) underwent either radiofrequency ablation or cryoablation. The PN patients were younger at diagnosis (59 vs 68 years, P < 0.001), more likely to be married (70% vs 64%, P < 0.001), and had smaller tumours (2.4 vs 2.6 cm, P < 0.001). There were no differences in the distribution of histology between the PN and ablation groups. Tumour grade was significantly lower in tumours treated with ablation. Compared with grade 1 disease, those undergoing ablation were 30% less likely to have grade 2 (P < 0.001), 30% less likely to have grade 3 (P < 0.001), and 92% less likely to have grade 4 disease (P < 0.01) than those having PN. Conclusions There is a strong association between grade and treatment type in patients with small renal masses after controlling for baseline characteristics. As grade is determined by different methods, we think that this shows systematic under-grading in biopsy of small renal masses.

AB - Objective To determine whether differences exist in tumour grade between patients who undergo partial nephrectomy (PN) and those who undergo ablation for renal tumours. Patients and Methods Data was obtained using the Surveillance, Epidemiology and End Results database. Patients with solitary renal tumours of <4 cm treated with ablation or PN and with renal cell carcinoma (RCC) histopathology were identified. Tissue diagnosis in the ablation specimens was obtained from biopsy reports, whereas tissue from PN specimens was determined from surgical pathology. Variables analysed included: year of diagnosis, age, sex, race/ethnicity, marital status, population density, education, poverty level, and tumour size. Stacked bar graphs were created to compare the distributions of grade and histology between the groups. Multinomial logistic regression was used to determine factors independently associated with grade. Results In all, 7704 (87.4%) patients underwent PN and 1114 (12.6%) underwent either radiofrequency ablation or cryoablation. The PN patients were younger at diagnosis (59 vs 68 years, P < 0.001), more likely to be married (70% vs 64%, P < 0.001), and had smaller tumours (2.4 vs 2.6 cm, P < 0.001). There were no differences in the distribution of histology between the PN and ablation groups. Tumour grade was significantly lower in tumours treated with ablation. Compared with grade 1 disease, those undergoing ablation were 30% less likely to have grade 2 (P < 0.001), 30% less likely to have grade 3 (P < 0.001), and 92% less likely to have grade 4 disease (P < 0.01) than those having PN. Conclusions There is a strong association between grade and treatment type in patients with small renal masses after controlling for baseline characteristics. As grade is determined by different methods, we think that this shows systematic under-grading in biopsy of small renal masses.

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