Uncovering a tumor suppressor for triple-negative breast cancers

John Albeck; Joan S. Brugge

doi:10.1016/j.cell.2011.02.030

Uncovering a tumor suppressor for triple-negative breast cancers

John Albeck, Joan S. Brugge

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

"Triple-negative" breast cancers are aggressive malignancies that respond poorly to treatments. Now Sun et al. (2011) find that the activity of the protein tyrosine phosphatase PTPN12 is lost in a large percentage of this breast cancer subtype, offering molecular drivers and possible therapeutic targets for this heterogeneous and intractable cancer.

Original language	English (US)
Pages (from-to)	638-640
Number of pages	3
Journal	Cell
Volume	144
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2011.02.030
State	Published - Mar 4 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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AU - Brugge, Joan S.

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AB - "Triple-negative" breast cancers are aggressive malignancies that respond poorly to treatments. Now Sun et al. (2011) find that the activity of the protein tyrosine phosphatase PTPN12 is lost in a large percentage of this breast cancer subtype, offering molecular drivers and possible therapeutic targets for this heterogeneous and intractable cancer.

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Uncovering a tumor suppressor for triple-negative breast cancers

Abstract

ASJC Scopus subject areas

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