Uncoupling proteins, dietary fat and the metabolic syndrome

Janis S. Fisler, Craig H Warden

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

There has been intense interest in defining the functions of UCP2 and UCP3 during the nine years since the cloning of these UCP1 homologues. Current data suggest that both UCP2 and UCP3 proteins share some features with UCP1, such as the ability to reduce mitochondrial membrane potential, but they also have distinctly different physiological roles. Human genetic studies consistently demonstrate the effect of UCP2 alleles on type-2 diabetes. Less clear is whether UCP2 alleles influence body weight or body mass index (BMI) with many studies showing a positive effect while others do not. There is strong evidence that both UCP2 and UCP3 protect against mitochondrial oxidative damage by reducing the production of reactive oxygen species. The evidence that UCP2 protein is a negative regulator of insulin secretion by pancreatic β-cells is also strong: increased UCP2 decreases glucose stimulated insulin secretion ultimately leading to β-cell dysfunction. UCP2 is also neuroprotective, reducing oxidative stress in neurons. UCP3 may also transport fatty acids out of mitochondria thereby protecting the mitochondria from fatty acid anions or peroxides. Current data suggest that UCP2 plays a role in the metabolic syndrome through down-regulation of insulin secretion and development of type-2 diabetes. However, UCP2 may protect against atherosclerosis through reduction of oxidative stress and both UCP2 and UCP3 may protect against obesity. Thus, these UCP1 homologues may both contribute to and protect from the markers of the metabolic syndrome.

Original languageEnglish (US)
Article number38
JournalNutrition and Metabolism
Volume3
DOIs
StatePublished - Sep 12 2006

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Dietary Fats
Insulin
Type 2 Diabetes Mellitus
Mitochondria
Oxidative Stress
Fatty Acids
Alleles
Mitochondrial Membrane Potential
Peroxides
Medical Genetics
Anions
Organism Cloning
Reactive Oxygen Species
Atherosclerosis
Body Mass Index
Down-Regulation
Obesity
Body Weight
Neurons
Glucose

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Uncoupling proteins, dietary fat and the metabolic syndrome. / Fisler, Janis S.; Warden, Craig H.

In: Nutrition and Metabolism, Vol. 3, 38, 12.09.2006.

Research output: Contribution to journalArticle

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