Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold

Balazs Horvath, Claudia Spies, Gyongyi Horvath, Wolfgang J. Kox, Suzanne Miyamoto, Sean Barry, Craig H Warden, Ingo Bechmann, Sabrina Diano, Jill Heemskerk, Tamas L. Horvath

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Abuse of ethanol is a major risk factor in medicine, in part because of its widespread effect on the activity of the central nervous system, including behavior, pain, and temperature sensation. Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. Its expression in mitochondria of axons and axon terminals of basal forebrain areas suggests that UCP2 may be involved in the regulation of complex neuronal responses to ethanol. We employed a paradigm in which acute exposure to ethanol induces tolerance and altered pain and temperature sensation. In UCP2 overexpressing mice, sensitivity to ethanol was decreased compared to that of wild-type animals, while UCP2 knockouts had increased ethanol sensitivity. In addition, UCP2 expression was inversely correlated with the impairment of pain and temperature sensation induced by ethanol. Taken together, these results indicate that UCP2, a mitochondrial uncoupling protein previously associated with peripheral energy expenditure, is involved in the mediation of acute ethanol exposure on the central nervous system. Enhancement of UCP2 activation after acute alcohol consumption might decrease the time of recovery from intoxication, whereas UCP2 inhibition might decrease the tolerance to ethanol.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalBiochemical Pharmacology
Volume64
Issue number3
DOIs
StatePublished - Aug 1 2002

Fingerprint

Pain Threshold
Ethanol
Alcohols
Proteins
Pain
Neurology
Temperature
Central Nervous System
Wild Animals
Uncoupling Protein 2
Presynaptic Terminals
Mitochondria
Alcohol Drinking
Energy Metabolism
Axons
Medicine
Homeostasis
Animals
Chemical activation
Recovery

Keywords

  • Central nervous system
  • Ethanol tolerance
  • Knockout animals
  • Nociception
  • Transgenic animals
  • Uncoupling proteins

ASJC Scopus subject areas

  • Pharmacology

Cite this

Horvath, B., Spies, C., Horvath, G., Kox, W. J., Miyamoto, S., Barry, S., ... Horvath, T. L. (2002). Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochemical Pharmacology, 64(3), 369-374. https://doi.org/10.1016/S0006-2952(02)01167-X

Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. / Horvath, Balazs; Spies, Claudia; Horvath, Gyongyi; Kox, Wolfgang J.; Miyamoto, Suzanne; Barry, Sean; Warden, Craig H; Bechmann, Ingo; Diano, Sabrina; Heemskerk, Jill; Horvath, Tamas L.

In: Biochemical Pharmacology, Vol. 64, No. 3, 01.08.2002, p. 369-374.

Research output: Contribution to journalArticle

Horvath, B, Spies, C, Horvath, G, Kox, WJ, Miyamoto, S, Barry, S, Warden, CH, Bechmann, I, Diano, S, Heemskerk, J & Horvath, TL 2002, 'Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold', Biochemical Pharmacology, vol. 64, no. 3, pp. 369-374. https://doi.org/10.1016/S0006-2952(02)01167-X
Horvath B, Spies C, Horvath G, Kox WJ, Miyamoto S, Barry S et al. Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochemical Pharmacology. 2002 Aug 1;64(3):369-374. https://doi.org/10.1016/S0006-2952(02)01167-X
Horvath, Balazs ; Spies, Claudia ; Horvath, Gyongyi ; Kox, Wolfgang J. ; Miyamoto, Suzanne ; Barry, Sean ; Warden, Craig H ; Bechmann, Ingo ; Diano, Sabrina ; Heemskerk, Jill ; Horvath, Tamas L. / Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. In: Biochemical Pharmacology. 2002 ; Vol. 64, No. 3. pp. 369-374.
@article{6fdc7f4458bd4c3a9ade2915c4a24f94,
title = "Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold",
abstract = "Abuse of ethanol is a major risk factor in medicine, in part because of its widespread effect on the activity of the central nervous system, including behavior, pain, and temperature sensation. Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. Its expression in mitochondria of axons and axon terminals of basal forebrain areas suggests that UCP2 may be involved in the regulation of complex neuronal responses to ethanol. We employed a paradigm in which acute exposure to ethanol induces tolerance and altered pain and temperature sensation. In UCP2 overexpressing mice, sensitivity to ethanol was decreased compared to that of wild-type animals, while UCP2 knockouts had increased ethanol sensitivity. In addition, UCP2 expression was inversely correlated with the impairment of pain and temperature sensation induced by ethanol. Taken together, these results indicate that UCP2, a mitochondrial uncoupling protein previously associated with peripheral energy expenditure, is involved in the mediation of acute ethanol exposure on the central nervous system. Enhancement of UCP2 activation after acute alcohol consumption might decrease the time of recovery from intoxication, whereas UCP2 inhibition might decrease the tolerance to ethanol.",
keywords = "Central nervous system, Ethanol tolerance, Knockout animals, Nociception, Transgenic animals, Uncoupling proteins",
author = "Balazs Horvath and Claudia Spies and Gyongyi Horvath and Kox, {Wolfgang J.} and Suzanne Miyamoto and Sean Barry and Warden, {Craig H} and Ingo Bechmann and Sabrina Diano and Jill Heemskerk and Horvath, {Tamas L.}",
year = "2002",
month = "8",
day = "1",
doi = "10.1016/S0006-2952(02)01167-X",
language = "English (US)",
volume = "64",
pages = "369--374",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold

AU - Horvath, Balazs

AU - Spies, Claudia

AU - Horvath, Gyongyi

AU - Kox, Wolfgang J.

AU - Miyamoto, Suzanne

AU - Barry, Sean

AU - Warden, Craig H

AU - Bechmann, Ingo

AU - Diano, Sabrina

AU - Heemskerk, Jill

AU - Horvath, Tamas L.

PY - 2002/8/1

Y1 - 2002/8/1

N2 - Abuse of ethanol is a major risk factor in medicine, in part because of its widespread effect on the activity of the central nervous system, including behavior, pain, and temperature sensation. Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. Its expression in mitochondria of axons and axon terminals of basal forebrain areas suggests that UCP2 may be involved in the regulation of complex neuronal responses to ethanol. We employed a paradigm in which acute exposure to ethanol induces tolerance and altered pain and temperature sensation. In UCP2 overexpressing mice, sensitivity to ethanol was decreased compared to that of wild-type animals, while UCP2 knockouts had increased ethanol sensitivity. In addition, UCP2 expression was inversely correlated with the impairment of pain and temperature sensation induced by ethanol. Taken together, these results indicate that UCP2, a mitochondrial uncoupling protein previously associated with peripheral energy expenditure, is involved in the mediation of acute ethanol exposure on the central nervous system. Enhancement of UCP2 activation after acute alcohol consumption might decrease the time of recovery from intoxication, whereas UCP2 inhibition might decrease the tolerance to ethanol.

AB - Abuse of ethanol is a major risk factor in medicine, in part because of its widespread effect on the activity of the central nervous system, including behavior, pain, and temperature sensation. Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. Its expression in mitochondria of axons and axon terminals of basal forebrain areas suggests that UCP2 may be involved in the regulation of complex neuronal responses to ethanol. We employed a paradigm in which acute exposure to ethanol induces tolerance and altered pain and temperature sensation. In UCP2 overexpressing mice, sensitivity to ethanol was decreased compared to that of wild-type animals, while UCP2 knockouts had increased ethanol sensitivity. In addition, UCP2 expression was inversely correlated with the impairment of pain and temperature sensation induced by ethanol. Taken together, these results indicate that UCP2, a mitochondrial uncoupling protein previously associated with peripheral energy expenditure, is involved in the mediation of acute ethanol exposure on the central nervous system. Enhancement of UCP2 activation after acute alcohol consumption might decrease the time of recovery from intoxication, whereas UCP2 inhibition might decrease the tolerance to ethanol.

KW - Central nervous system

KW - Ethanol tolerance

KW - Knockout animals

KW - Nociception

KW - Transgenic animals

KW - Uncoupling proteins

UR - http://www.scopus.com/inward/record.url?scp=0036684531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036684531&partnerID=8YFLogxK

U2 - 10.1016/S0006-2952(02)01167-X

DO - 10.1016/S0006-2952(02)01167-X

M3 - Article

C2 - 12147287

AN - SCOPUS:0036684531

VL - 64

SP - 369

EP - 374

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

IS - 3

ER -