Abstract
Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. In this study, we explored the expression of UCP2 in the spinal cord. UCP2 was expressed in the substantia gelatinosa and ventral horn of the rodent and primate spinal cord. In all of these areas, UCP2 expression was associated with axons and axon terminals and direct appositions between UCP2-immunoreactive fibers and NMDA glutamate receptors-containing perikarya were frequently detected. All of the UCP2-labeled processes were also immunoreactive for substance P. The expression of UCP2 in primary sensory afferents of the spinal cord suggests that this mitochondrial uncoupler is involved in the mechanism of pain and temperature sensation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 260-263 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 955 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 15 2002 |
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Keywords
- Spinal Cord
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord. / Horvath, Balazs; Spies, Claudia; Warden, Craig H; Diano, Sabrina; Horvath, Tamas L.
In: Brain Research, Vol. 955, No. 1-2, 15.11.2002, p. 260-263.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord
AU - Horvath, Balazs
AU - Spies, Claudia
AU - Warden, Craig H
AU - Diano, Sabrina
AU - Horvath, Tamas L.
PY - 2002/11/15
Y1 - 2002/11/15
N2 - Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. In this study, we explored the expression of UCP2 in the spinal cord. UCP2 was expressed in the substantia gelatinosa and ventral horn of the rodent and primate spinal cord. In all of these areas, UCP2 expression was associated with axons and axon terminals and direct appositions between UCP2-immunoreactive fibers and NMDA glutamate receptors-containing perikarya were frequently detected. All of the UCP2-labeled processes were also immunoreactive for substance P. The expression of UCP2 in primary sensory afferents of the spinal cord suggests that this mitochondrial uncoupler is involved in the mechanism of pain and temperature sensation.
AB - Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. In this study, we explored the expression of UCP2 in the spinal cord. UCP2 was expressed in the substantia gelatinosa and ventral horn of the rodent and primate spinal cord. In all of these areas, UCP2 expression was associated with axons and axon terminals and direct appositions between UCP2-immunoreactive fibers and NMDA glutamate receptors-containing perikarya were frequently detected. All of the UCP2-labeled processes were also immunoreactive for substance P. The expression of UCP2 in primary sensory afferents of the spinal cord suggests that this mitochondrial uncoupler is involved in the mechanism of pain and temperature sensation.
KW - Spinal Cord
UR - http://www.scopus.com/inward/record.url?scp=0037111159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037111159&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(02)03364-4
DO - 10.1016/S0006-8993(02)03364-4
M3 - Article
C2 - 12419545
AN - SCOPUS:0037111159
VL - 955
SP - 260
EP - 263
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -