Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord

Balazs Horvath, Claudia Spies, Craig H Warden, Sabrina Diano, Tamas L. Horvath

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. In this study, we explored the expression of UCP2 in the spinal cord. UCP2 was expressed in the substantia gelatinosa and ventral horn of the rodent and primate spinal cord. In all of these areas, UCP2 expression was associated with axons and axon terminals and direct appositions between UCP2-immunoreactive fibers and NMDA glutamate receptors-containing perikarya were frequently detected. All of the UCP2-labeled processes were also immunoreactive for substance P. The expression of UCP2 in primary sensory afferents of the spinal cord suggests that this mitochondrial uncoupler is involved in the mechanism of pain and temperature sensation.

Original languageEnglish (US)
Pages (from-to)260-263
Number of pages4
JournalBrain Research
Volume955
Issue number1-2
DOIs
StatePublished - Nov 15 2002

Fingerprint

Spinal Cord
Pain
Temperature
Substantia Gelatinosa
Presynaptic Terminals
Glutamate Receptors
Horns
Substance P
Uncoupling Protein 2
N-Methyl-D-Aspartate Receptors
Primates
Axons
Rodentia
Homeostasis

Keywords

  • Spinal Cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord. / Horvath, Balazs; Spies, Claudia; Warden, Craig H; Diano, Sabrina; Horvath, Tamas L.

In: Brain Research, Vol. 955, No. 1-2, 15.11.2002, p. 260-263.

Research output: Contribution to journalArticle

Horvath, Balazs ; Spies, Claudia ; Warden, Craig H ; Diano, Sabrina ; Horvath, Tamas L. / Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord. In: Brain Research. 2002 ; Vol. 955, No. 1-2. pp. 260-263.
@article{b45bf92044bb49bd884583b91b766e25,
title = "Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord",
abstract = "Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. In this study, we explored the expression of UCP2 in the spinal cord. UCP2 was expressed in the substantia gelatinosa and ventral horn of the rodent and primate spinal cord. In all of these areas, UCP2 expression was associated with axons and axon terminals and direct appositions between UCP2-immunoreactive fibers and NMDA glutamate receptors-containing perikarya were frequently detected. All of the UCP2-labeled processes were also immunoreactive for substance P. The expression of UCP2 in primary sensory afferents of the spinal cord suggests that this mitochondrial uncoupler is involved in the mechanism of pain and temperature sensation.",
keywords = "Spinal Cord",
author = "Balazs Horvath and Claudia Spies and Warden, {Craig H} and Sabrina Diano and Horvath, {Tamas L.}",
year = "2002",
month = "11",
day = "15",
doi = "10.1016/S0006-8993(02)03364-4",
language = "English (US)",
volume = "955",
pages = "260--263",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord

AU - Horvath, Balazs

AU - Spies, Claudia

AU - Warden, Craig H

AU - Diano, Sabrina

AU - Horvath, Tamas L.

PY - 2002/11/15

Y1 - 2002/11/15

N2 - Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. In this study, we explored the expression of UCP2 in the spinal cord. UCP2 was expressed in the substantia gelatinosa and ventral horn of the rodent and primate spinal cord. In all of these areas, UCP2 expression was associated with axons and axon terminals and direct appositions between UCP2-immunoreactive fibers and NMDA glutamate receptors-containing perikarya were frequently detected. All of the UCP2-labeled processes were also immunoreactive for substance P. The expression of UCP2 in primary sensory afferents of the spinal cord suggests that this mitochondrial uncoupler is involved in the mechanism of pain and temperature sensation.

AB - Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. In this study, we explored the expression of UCP2 in the spinal cord. UCP2 was expressed in the substantia gelatinosa and ventral horn of the rodent and primate spinal cord. In all of these areas, UCP2 expression was associated with axons and axon terminals and direct appositions between UCP2-immunoreactive fibers and NMDA glutamate receptors-containing perikarya were frequently detected. All of the UCP2-labeled processes were also immunoreactive for substance P. The expression of UCP2 in primary sensory afferents of the spinal cord suggests that this mitochondrial uncoupler is involved in the mechanism of pain and temperature sensation.

KW - Spinal Cord

UR - http://www.scopus.com/inward/record.url?scp=0037111159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037111159&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(02)03364-4

DO - 10.1016/S0006-8993(02)03364-4

M3 - Article

C2 - 12419545

AN - SCOPUS:0037111159

VL - 955

SP - 260

EP - 263

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -