Ultrastructural analysis of platelets and megakaryocytes from a dog with probable essential thrombocythemia.

Fern Tablin, N. C. Jain, C. P. Mandell, P. E. Hopper, J. G. Zinkl

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Abstract

Blood platelets and bone marrow megakaryocytes from a dog with essential thrombocythemia were analyzed by transmission electron microscopy and compared with those of control dogs. Platelets varied in size and shape and contained enlarged and dilated open canalicular systems. Megakaryocytes were dysmorphic and had evidence of abnormal maturation, with large numbers of megakaryoblasts containing alpha granules and poorly organized and reduplicated demarcation membranes. The fewer, more mature megakaryocytes lacked normal cytoplasmic organization. Most notable was the absence of well-demarcated "platelet fields," due to the excessive and disorderly array of demarcation membranes.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalVeterinary Pathology
Volume26
Issue number4
StatePublished - Jul 1989

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ASJC Scopus subject areas

  • veterinary(all)

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