Ultrasound microbubble contrast agents: Fundamentals and application to gene and drug delivery

Katherine Ferrara, Rachel E Pollard, Mark Borden

Research output: Contribution to journalArticlepeer-review

885 Scopus citations


This review offers a critical analysis of the state of the art of medical microbubbles and their application in therapeutic delivery and monitoring. When driven by an ultrasonic pulse, these small gas bubbles oscillate with a wall velocity on the order of tens to hundreds of meters per second and can be deflected to a vessel wall or fragmented into particles on the order of nanometers. While single-session molecular imaging of multiple targets is difficult with affinity-based strategies employed in some other imaging modalities, microbubble fragmentation facilitates such studies. Similarly, a focused ultrasound beam can be used to disrupt delivery vehicles and blood vessel walls, offering the opportunity to locally deliver a drug or gene. Clinical translation of these vehicles will require that current challenges be overcome, where these challenges include rapid clearance and low payload. The technology, early successes with drug and gene delivery, and potential clinical applications are reviewed.

Original languageEnglish (US)
Pages (from-to)415-447
Number of pages33
JournalAnnual Review of Biomedical Engineering
StatePublished - 2007


  • Cavitation
  • Chemotherapy
  • Controlled release
  • DNA
  • Radiation force
  • Sonoporation

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering


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