Abstract
When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 |
| Pages | 134-136 |
| Number of pages | 3 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
| Event | 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009 |
Other
| Other | 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 |
|---|---|
| Country | United States |
| City | Minneapolis, MN |
| Period | 9/2/09 → 9/6/09 |
Fingerprint
ASJC Scopus subject areas
- Cell Biology
- Developmental Biology
- Biomedical Engineering
- Medicine(all)
Cite this
Ultrasound mediated drug delivery : The effect of microbubbles on a gel boundary. / Caskey, Charles F.; Qin, Shengping; Ferrara, Katherine W.
Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 134-136 5335240.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Ultrasound mediated drug delivery
T2 - The effect of microbubbles on a gel boundary
AU - Caskey, Charles F.
AU - Qin, Shengping
AU - Ferrara, Katherine W.
PY - 2009
Y1 - 2009
N2 - When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.
AB - When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.
UR - http://www.scopus.com/inward/record.url?scp=77950967156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950967156&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5335240
DO - 10.1109/IEMBS.2009.5335240
M3 - Conference contribution
AN - SCOPUS:77950967156
SN - 9781424432967
SP - 134
EP - 136
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
ER -