Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary

Charles F. Caskey; Shengping Qin; Katherine W. Ferrara

doi:10.1109/IEMBS.2009.5335240

Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary

Charles F. Caskey, Shengping Qin, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.

Original language	English (US)
Title of host publication	Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages	134-136
Number of pages	3
DOIs	https://doi.org/10.1109/IEMBS.2009.5335240
State	Published - 2009
Externally published	Yes
Event	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009

Other

Other	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Country	United States
City	Minneapolis, MN
Period	9/2/09 → 9/6/09

ASJC Scopus subject areas

Cell Biology
Developmental Biology
Biomedical Engineering
Medicine(all)

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Ultrasound mediated drug delivery : The effect of microbubbles on a gel boundary. / Caskey, Charles F.; Qin, Shengping; Ferrara, Katherine W.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 134-136 5335240.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Caskey, CF, Qin, S & Ferrara, KW 2009, Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5335240, pp. 134-136, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5335240

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abstract = "When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.",

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Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary

Abstract

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