Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary

Charles F. Caskey; Shengping Qin; Katherine W. Ferrara

doi:10.1109/IEMBS.2009.5335240

Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary

Charles F. Caskey, Shengping Qin, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.

Original language	English (US)
Title of host publication	Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages	134-136
Number of pages	3
DOIs	https://doi.org/10.1109/IEMBS.2009.5335240
State	Published - 2009
Externally published	Yes
Event	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009

Other

Other	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Country/Territory	United States
City	Minneapolis, MN
Period	9/2/09 → 9/6/09

ASJC Scopus subject areas

Cell Biology
Developmental Biology
Biomedical Engineering
Medicine(all)

Access to Document

10.1109/IEMBS.2009.5335240

Cite this

Ultrasound mediated drug delivery : The effect of microbubbles on a gel boundary. / Caskey, Charles F.; Qin, Shengping; Ferrara, Katherine W.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 134-136 5335240.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Caskey, CF, Qin, S & Ferrara, KW 2009, Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5335240, pp. 134-136, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5335240

@inproceedings{1414e847f4254f469d8926fe95a606bf,

title = "Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary",

abstract = "When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.",

author = "Caskey, {Charles F.} and Shengping Qin and Ferrara, {Katherine W.}",

year = "2009",

doi = "10.1109/IEMBS.2009.5335240",

language = "English (US)",

isbn = "9781424432967",

pages = "134--136",

booktitle = "Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009",

note = "31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 ; Conference date: 02-09-2009 Through 06-09-2009",

}

TY - GEN

T1 - Ultrasound mediated drug delivery

T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

AU - Caskey, Charles F.

AU - Qin, Shengping

AU - Ferrara, Katherine W.

PY - 2009

Y1 - 2009

N2 - When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.

AB - When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.

UR - http://www.scopus.com/inward/record.url?scp=77950967156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950967156&partnerID=8YFLogxK

U2 - 10.1109/IEMBS.2009.5335240

DO - 10.1109/IEMBS.2009.5335240

M3 - Conference contribution

AN - SCOPUS:77950967156

SN - 9781424432967

SP - 134

EP - 136

BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Y2 - 2 September 2009 through 6 September 2009

ER -

Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary

Abstract

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this