Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary

Charles F. Caskey, Shengping Qin, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized. Here, we use a gel phantom with a Young's modulus similar to that of tissue to directly observe bubble interaction with the gel surface during insonation. Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages134-136
Number of pages3
DOIs
StatePublished - 2009
Externally publishedYes
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Microbubbles
Drug delivery
Acoustics
Gels
Ultrasonics
Elastic Modulus
Blood vessels
Diagnostic Imaging
Cell membranes
Pharmaceutical Preparations
Contrast Media
Blood Vessels
Tunnels
Elastic moduli
Cell Membrane
Acoustic waves
Tissue
Imaging techniques
Fluids

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Caskey, C. F., Qin, S., & Ferrara, K. W. (2009). Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 134-136). [5335240] https://doi.org/10.1109/IEMBS.2009.5335240

Ultrasound mediated drug delivery : The effect of microbubbles on a gel boundary. / Caskey, Charles F.; Qin, Shengping; Ferrara, Katherine W.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 134-136 5335240.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Caskey, CF, Qin, S & Ferrara, KW 2009, Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5335240, pp. 134-136, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5335240
Caskey CF, Qin S, Ferrara KW. Ultrasound mediated drug delivery: The effect of microbubbles on a gel boundary. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 134-136. 5335240 https://doi.org/10.1109/IEMBS.2009.5335240
Caskey, Charles F. ; Qin, Shengping ; Ferrara, Katherine W. / Ultrasound mediated drug delivery : The effect of microbubbles on a gel boundary. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. pp. 134-136
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