Ultrasound contrast agents used for localized drug delivery

Donovan May, Paul Dayton, James Chomas, John Allen, Kathy Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

The delivery of chemotherapy can be improved and localized using engineered drug delivery vehicles. Localized drug delivery would decrease the systemic side effects of toxic chemotherapy drugs. The unique delivery agents we are examining are provided by ImaRx Pharmaceuticals, and consist of an outer lipid shell with an inner oil layer and a gas core. The three microsphere types investigated contained soybean oil, corn oil, and triacetin, within the outer layer. These structures are 0.5-8 μm in diameter at rest and thus can carry a large payload compared to nano-scale drug delivery systems. The oil shells of these delivery agents can be loaded with paclitaxel or other hydrophobic drugs. Oil layers of these acoustically active lipospheres (AALs) range from 0.3-1.5 μm in thickness. We show these drug delivery vehicles can be fragmented using ultrasound thus releasing their payload in a localized area.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
EditorsS.C. Schneider, M. Levy, B.R. McAvoy
Pages1429-1432
Number of pages4
Volume2
StatePublished - 2000
Event2000 IEEE Ultrasonics Symposium - San Juan, Puerto Rico
Duration: Oct 22 2000Oct 25 2000

Other

Other2000 IEEE Ultrasonics Symposium
CountryPuerto Rico
CitySan Juan
Period10/22/0010/25/00

ASJC Scopus subject areas

  • Engineering(all)

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