Ultrasound contrast agents used for localized drug delivery

Donovan May, Paul Dayton, James Chomas, John Allen, Kathy Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

The delivery of chemotherapy can be improved and localized using engineered drug delivery vehicles. Localized drug delivery would decrease the systemic side effects of toxic chemotherapy drugs. The unique delivery agents we are examining are provided by ImaRx Pharmaceuticals, and consist of an outer lipid shell with an inner oil layer and a gas core. The three microsphere types investigated contained soybean oil, corn oil, and triacetin, within the outer layer. These structures are 0.5-8 μm in diameter at rest and thus can carry a large payload compared to nano-scale drug delivery systems. The oil shells of these delivery agents can be loaded with paclitaxel or other hydrophobic drugs. Oil layers of these acoustically active lipospheres (AALs) range from 0.3-1.5 μm in thickness. We show these drug delivery vehicles can be fragmented using ultrasound thus releasing their payload in a localized area.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
EditorsS.C. Schneider, M. Levy, B.R. McAvoy
Pages1429-1432
Number of pages4
Volume2
StatePublished - 2000
Event2000 IEEE Ultrasonics Symposium - San Juan, Puerto Rico
Duration: Oct 22 2000Oct 25 2000

Other

Other2000 IEEE Ultrasonics Symposium
CountryPuerto Rico
CitySan Juan
Period10/22/0010/25/00

Fingerprint

Drug delivery
Ultrasonics
Chemotherapy
Soybean oil
Microspheres
Drug products
Lipids
Oils
Gases

ASJC Scopus subject areas

  • Engineering(all)

Cite this

May, D., Dayton, P., Chomas, J., Allen, J., & Ferrara, K. (2000). Ultrasound contrast agents used for localized drug delivery. In S. C. Schneider, M. Levy, & B. R. McAvoy (Eds.), Proceedings of the IEEE Ultrasonics Symposium (Vol. 2, pp. 1429-1432)

Ultrasound contrast agents used for localized drug delivery. / May, Donovan; Dayton, Paul; Chomas, James; Allen, John; Ferrara, Kathy.

Proceedings of the IEEE Ultrasonics Symposium. ed. / S.C. Schneider; M. Levy; B.R. McAvoy. Vol. 2 2000. p. 1429-1432.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

May, D, Dayton, P, Chomas, J, Allen, J & Ferrara, K 2000, Ultrasound contrast agents used for localized drug delivery. in SC Schneider, M Levy & BR McAvoy (eds), Proceedings of the IEEE Ultrasonics Symposium. vol. 2, pp. 1429-1432, 2000 IEEE Ultrasonics Symposium, San Juan, Puerto Rico, 10/22/00.
May D, Dayton P, Chomas J, Allen J, Ferrara K. Ultrasound contrast agents used for localized drug delivery. In Schneider SC, Levy M, McAvoy BR, editors, Proceedings of the IEEE Ultrasonics Symposium. Vol. 2. 2000. p. 1429-1432
May, Donovan ; Dayton, Paul ; Chomas, James ; Allen, John ; Ferrara, Kathy. / Ultrasound contrast agents used for localized drug delivery. Proceedings of the IEEE Ultrasonics Symposium. editor / S.C. Schneider ; M. Levy ; B.R. McAvoy. Vol. 2 2000. pp. 1429-1432
@inproceedings{b7112d0c0ad54b9b8fed4776bccd0d70,
title = "Ultrasound contrast agents used for localized drug delivery",
abstract = "The delivery of chemotherapy can be improved and localized using engineered drug delivery vehicles. Localized drug delivery would decrease the systemic side effects of toxic chemotherapy drugs. The unique delivery agents we are examining are provided by ImaRx Pharmaceuticals, and consist of an outer lipid shell with an inner oil layer and a gas core. The three microsphere types investigated contained soybean oil, corn oil, and triacetin, within the outer layer. These structures are 0.5-8 μm in diameter at rest and thus can carry a large payload compared to nano-scale drug delivery systems. The oil shells of these delivery agents can be loaded with paclitaxel or other hydrophobic drugs. Oil layers of these acoustically active lipospheres (AALs) range from 0.3-1.5 μm in thickness. We show these drug delivery vehicles can be fragmented using ultrasound thus releasing their payload in a localized area.",
author = "Donovan May and Paul Dayton and James Chomas and John Allen and Kathy Ferrara",
year = "2000",
language = "English (US)",
volume = "2",
pages = "1429--1432",
editor = "S.C. Schneider and M. Levy and B.R. McAvoy",
booktitle = "Proceedings of the IEEE Ultrasonics Symposium",

}

TY - GEN

T1 - Ultrasound contrast agents used for localized drug delivery

AU - May, Donovan

AU - Dayton, Paul

AU - Chomas, James

AU - Allen, John

AU - Ferrara, Kathy

PY - 2000

Y1 - 2000

N2 - The delivery of chemotherapy can be improved and localized using engineered drug delivery vehicles. Localized drug delivery would decrease the systemic side effects of toxic chemotherapy drugs. The unique delivery agents we are examining are provided by ImaRx Pharmaceuticals, and consist of an outer lipid shell with an inner oil layer and a gas core. The three microsphere types investigated contained soybean oil, corn oil, and triacetin, within the outer layer. These structures are 0.5-8 μm in diameter at rest and thus can carry a large payload compared to nano-scale drug delivery systems. The oil shells of these delivery agents can be loaded with paclitaxel or other hydrophobic drugs. Oil layers of these acoustically active lipospheres (AALs) range from 0.3-1.5 μm in thickness. We show these drug delivery vehicles can be fragmented using ultrasound thus releasing their payload in a localized area.

AB - The delivery of chemotherapy can be improved and localized using engineered drug delivery vehicles. Localized drug delivery would decrease the systemic side effects of toxic chemotherapy drugs. The unique delivery agents we are examining are provided by ImaRx Pharmaceuticals, and consist of an outer lipid shell with an inner oil layer and a gas core. The three microsphere types investigated contained soybean oil, corn oil, and triacetin, within the outer layer. These structures are 0.5-8 μm in diameter at rest and thus can carry a large payload compared to nano-scale drug delivery systems. The oil shells of these delivery agents can be loaded with paclitaxel or other hydrophobic drugs. Oil layers of these acoustically active lipospheres (AALs) range from 0.3-1.5 μm in thickness. We show these drug delivery vehicles can be fragmented using ultrasound thus releasing their payload in a localized area.

UR - http://www.scopus.com/inward/record.url?scp=0034579348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034579348&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0034579348

VL - 2

SP - 1429

EP - 1432

BT - Proceedings of the IEEE Ultrasonics Symposium

A2 - Schneider, S.C.

A2 - Levy, M.

A2 - McAvoy, B.R.

ER -