Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity

Paul A. Dayton, Jonathan R. Lindner, James E. Chomas, Karen E. Morgan, Scott Simon, Aaron Lum, Donovan May, Matthew P. Coggins, Kathy W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations


A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
Number of pages4
StatePublished - 1999
Event1999 IEEE Ultrasonics Symposium - Caesars Tahoe, NV, USA
Duration: Oct 17 1999Oct 20 1999


Other1999 IEEE Ultrasonics Symposium
CityCaesars Tahoe, NV, USA

ASJC Scopus subject areas

  • Engineering(all)


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