Ultrasonic enhancement of drug penetration in solid tumors

Chun Yen Lai, Brett Z. Fite, Katherine W. Ferrara

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Increasing the penetration of drugs within solid tumors can be accomplished through multiple ultrasound-mediated mechanisms. The application of ultrasound can directly change the structure or physiology of tissues or can induce changes in a drug or vehicle in order to enhance delivery and efficacy. With each ultrasonic pulse, a fraction of the energy in the propagating wave is absorbed by tissue and results in local heating. When ultrasound is applied to achieve mild hyperthermia, the thermal effects are associated with an increase in perfusion or the release of a drug from a temperature-sensitive vehicle. Higher ultrasound intensities locally ablate tissue and result in increased drug accumulation surrounding the ablated region of interest. Further, the mechanical displacement induced by the ultrasound pulse can result in the nucleation, growth and collapse of gas bubbles. As a result of such cavitation, the permeability of a vessel wall or cell membrane can be increased. Finally, the radiation pressure of the propagating pulse can translate particles or tissues. In this perspective, we will review recent progress in ultrasound-mediated tumor delivery and the opportunities for clinical translation.

Original languageEnglish (US)
Article number00204
JournalFrontiers in Oncology
Volume3 AUG
DOIs
StatePublished - 2013

Fingerprint

Ultrasonics
Pharmaceutical Preparations
Neoplasms
Heating
Permeability
Fever
Perfusion
Hot Temperature
Gases
Cell Membrane
Radiation
Blood Pressure
Temperature
Growth

Keywords

  • Enhanced drug delivery
  • Sonoporation
  • Tumor penetration
  • Ultrasound
  • Vascular permeability

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ultrasonic enhancement of drug penetration in solid tumors. / Lai, Chun Yen; Fite, Brett Z.; Ferrara, Katherine W.

In: Frontiers in Oncology, Vol. 3 AUG, 00204, 2013.

Research output: Contribution to journalArticle

Lai, Chun Yen ; Fite, Brett Z. ; Ferrara, Katherine W. / Ultrasonic enhancement of drug penetration in solid tumors. In: Frontiers in Oncology. 2013 ; Vol. 3 AUG.
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