Abstract
Increasing the penetration of drugs within solid tumors can be accomplished through multiple ultrasound-mediated mechanisms. The application of ultrasound can directly change the structure or physiology of tissues or can induce changes in a drug or vehicle in order to enhance delivery and efficacy. With each ultrasonic pulse, a fraction of the energy in the propagating wave is absorbed by tissue and results in local heating. When ultrasound is applied to achieve mild hyperthermia, the thermal effects are associated with an increase in perfusion or the release of a drug from a temperature-sensitive vehicle. Higher ultrasound intensities locally ablate tissue and result in increased drug accumulation surrounding the ablated region of interest. Further, the mechanical displacement induced by the ultrasound pulse can result in the nucleation, growth and collapse of gas bubbles. As a result of such cavitation, the permeability of a vessel wall or cell membrane can be increased. Finally, the radiation pressure of the propagating pulse can translate particles or tissues. In this perspective, we will review recent progress in ultrasound-mediated tumor delivery and the opportunities for clinical translation.
| Original language | English (US) |
|---|---|
| Article number | 00204 |
| Journal | Frontiers in Oncology |
| Volume | 3 AUG |
| DOIs | |
| State | Published - 2013 |
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Keywords
- Enhanced drug delivery
- Sonoporation
- Tumor penetration
- Ultrasound
- Vascular permeability
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Ultrasonic enhancement of drug penetration in solid tumors. / Lai, Chun Yen; Fite, Brett Z.; Ferrara, Katherine W.
In: Frontiers in Oncology, Vol. 3 AUG, 00204, 2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ultrasonic enhancement of drug penetration in solid tumors
AU - Lai, Chun Yen
AU - Fite, Brett Z.
AU - Ferrara, Katherine W.
PY - 2013
Y1 - 2013
N2 - Increasing the penetration of drugs within solid tumors can be accomplished through multiple ultrasound-mediated mechanisms. The application of ultrasound can directly change the structure or physiology of tissues or can induce changes in a drug or vehicle in order to enhance delivery and efficacy. With each ultrasonic pulse, a fraction of the energy in the propagating wave is absorbed by tissue and results in local heating. When ultrasound is applied to achieve mild hyperthermia, the thermal effects are associated with an increase in perfusion or the release of a drug from a temperature-sensitive vehicle. Higher ultrasound intensities locally ablate tissue and result in increased drug accumulation surrounding the ablated region of interest. Further, the mechanical displacement induced by the ultrasound pulse can result in the nucleation, growth and collapse of gas bubbles. As a result of such cavitation, the permeability of a vessel wall or cell membrane can be increased. Finally, the radiation pressure of the propagating pulse can translate particles or tissues. In this perspective, we will review recent progress in ultrasound-mediated tumor delivery and the opportunities for clinical translation.
AB - Increasing the penetration of drugs within solid tumors can be accomplished through multiple ultrasound-mediated mechanisms. The application of ultrasound can directly change the structure or physiology of tissues or can induce changes in a drug or vehicle in order to enhance delivery and efficacy. With each ultrasonic pulse, a fraction of the energy in the propagating wave is absorbed by tissue and results in local heating. When ultrasound is applied to achieve mild hyperthermia, the thermal effects are associated with an increase in perfusion or the release of a drug from a temperature-sensitive vehicle. Higher ultrasound intensities locally ablate tissue and result in increased drug accumulation surrounding the ablated region of interest. Further, the mechanical displacement induced by the ultrasound pulse can result in the nucleation, growth and collapse of gas bubbles. As a result of such cavitation, the permeability of a vessel wall or cell membrane can be increased. Finally, the radiation pressure of the propagating pulse can translate particles or tissues. In this perspective, we will review recent progress in ultrasound-mediated tumor delivery and the opportunities for clinical translation.
KW - Enhanced drug delivery
KW - Sonoporation
KW - Tumor penetration
KW - Ultrasound
KW - Vascular permeability
UR - http://www.scopus.com/inward/record.url?scp=84888767550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888767550&partnerID=8YFLogxK
U2 - 10.3389/fonc.2013.00204
DO - 10.3389/fonc.2013.00204
M3 - Article
AN - SCOPUS:84888767550
VL - 3 AUG
JO - Frontiers in Oncology
JF - Frontiers in Oncology
SN - 2234-943X
M1 - 00204
ER -