Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes

Martin Gundersen, P. Thomas Vernier, Laura Marcu, Aimin Li, Xhumei Zhu, Ali Z. Gallam, Thomas Katsouleas, Clayton Young, Matthew Behrend, Cheryl M. Craft

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Citations (Scopus)

Abstract

This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.

Original languageEnglish (US)
Title of host publicationIEEE Conference Record of Power Modulator Symposium
EditorsL. Gordon
Pages667-670
Number of pages4
StatePublished - 2002
EventConference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop - Hollywood, CA, United States
Duration: Jun 30 2002Jul 3 2002

Other

OtherConference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop
CountryUnited States
CityHollywood, CA
Period6/30/027/3/02

Fingerprint

Lymphocytes
Cell death
Ultrashort pulses
Chemical activation
Electric fields
T-cells
Genes
Membranes

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Gundersen, M., Vernier, P. T., Marcu, L., Li, A., Zhu, X., Gallam, A. Z., ... Craft, C. M. (2002). Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. In L. Gordon (Ed.), IEEE Conference Record of Power Modulator Symposium (pp. 667-670)

Ultrashort pulse electroporation : Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. / Gundersen, Martin; Vernier, P. Thomas; Marcu, Laura; Li, Aimin; Zhu, Xhumei; Gallam, Ali Z.; Katsouleas, Thomas; Young, Clayton; Behrend, Matthew; Craft, Cheryl M.

IEEE Conference Record of Power Modulator Symposium. ed. / L. Gordon. 2002. p. 667-670.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gundersen, M, Vernier, PT, Marcu, L, Li, A, Zhu, X, Gallam, AZ, Katsouleas, T, Young, C, Behrend, M & Craft, CM 2002, Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. in L Gordon (ed.), IEEE Conference Record of Power Modulator Symposium. pp. 667-670, Conference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop, Hollywood, CA, United States, 6/30/02.
Gundersen M, Vernier PT, Marcu L, Li A, Zhu X, Gallam AZ et al. Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. In Gordon L, editor, IEEE Conference Record of Power Modulator Symposium. 2002. p. 667-670
Gundersen, Martin ; Vernier, P. Thomas ; Marcu, Laura ; Li, Aimin ; Zhu, Xhumei ; Gallam, Ali Z. ; Katsouleas, Thomas ; Young, Clayton ; Behrend, Matthew ; Craft, Cheryl M. / Ultrashort pulse electroporation : Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. IEEE Conference Record of Power Modulator Symposium. editor / L. Gordon. 2002. pp. 667-670
@inproceedings{f37808e88d814d00b58e166a06bc9c21,
title = "Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes",
abstract = "This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.",
author = "Martin Gundersen and Vernier, {P. Thomas} and Laura Marcu and Aimin Li and Xhumei Zhu and Gallam, {Ali Z.} and Thomas Katsouleas and Clayton Young and Matthew Behrend and Craft, {Cheryl M.}",
year = "2002",
language = "English (US)",
pages = "667--670",
editor = "L. Gordon",
booktitle = "IEEE Conference Record of Power Modulator Symposium",

}

TY - GEN

T1 - Ultrashort pulse electroporation

T2 - Applications of high pulsed electric fields to induced caspase activation of human lymphocytes

AU - Gundersen, Martin

AU - Vernier, P. Thomas

AU - Marcu, Laura

AU - Li, Aimin

AU - Zhu, Xhumei

AU - Gallam, Ali Z.

AU - Katsouleas, Thomas

AU - Young, Clayton

AU - Behrend, Matthew

AU - Craft, Cheryl M.

PY - 2002

Y1 - 2002

N2 - This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.

AB - This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.

UR - http://www.scopus.com/inward/record.url?scp=0036999187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036999187&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0036999187

SP - 667

EP - 670

BT - IEEE Conference Record of Power Modulator Symposium

A2 - Gordon, L.

ER -