Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes

Martin Gundersen; P. Thomas Vernier; Laura Marcu; Aimin Li; Xhumei Zhu; Ali Z. Gallam; Thomas Katsouleas; Clayton Young; Matthew Behrend; Cheryl M. Craft

Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes

Martin Gundersen, P. Thomas Vernier, Laura Marcu, Aimin Li, Xhumei Zhu, Ali Z. Gallam, Thomas Katsouleas, Clayton Young, Matthew Behrend, Cheryl M. Craft

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

22 Scopus citations

Abstract

This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.

Original language	English (US)
Title of host publication	IEEE Conference Record of Power Modulator Symposium
Editors	L. Gordon
Pages	667-670
Number of pages	4
State	Published - 2002
Event	Conference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop - Hollywood, CA, United States Duration: Jun 30 2002 → Jul 3 2002

Other

Other	Conference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop
Country/Territory	United States
City	Hollywood, CA
Period	6/30/02 → 7/3/02

ASJC Scopus subject areas

Electrical and Electronic Engineering

Cite this

Ultrashort pulse electroporation : Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. / Gundersen, Martin; Vernier, P. Thomas; Marcu, Laura; Li, Aimin; Zhu, Xhumei; Gallam, Ali Z.; Katsouleas, Thomas; Young, Clayton; Behrend, Matthew; Craft, Cheryl M.

IEEE Conference Record of Power Modulator Symposium. ed. / L. Gordon. 2002. p. 667-670.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gundersen, M, Vernier, PT, Marcu, L, Li, A, Zhu, X, Gallam, AZ, Katsouleas, T, Young, C, Behrend, M & Craft, CM 2002, Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. in L Gordon (ed.), IEEE Conference Record of Power Modulator Symposium. pp. 667-670, Conference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop, Hollywood, CA, United States, 6/30/02.

Gundersen, Martin ; Vernier, P. Thomas ; Marcu, Laura ; Li, Aimin ; Zhu, Xhumei ; Gallam, Ali Z. ; Katsouleas, Thomas ; Young, Clayton ; Behrend, Matthew ; Craft, Cheryl M. / Ultrashort pulse electroporation : Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. IEEE Conference Record of Power Modulator Symposium. editor / L. Gordon. 2002. pp. 667-670

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AB - This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.

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Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes

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ASJC Scopus subject areas

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