Abstract
This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.
| Original language | English (US) |
|---|---|
| Title of host publication | IEEE Conference Record of Power Modulator Symposium |
| Editors | L. Gordon |
| Pages | 667-670 |
| Number of pages | 4 |
| State | Published - 2002 |
| Event | Conference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop - Hollywood, CA, United States Duration: Jun 30 2002 → Jul 3 2002 |
Other
| Other | Conference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop |
|---|---|
| Country | United States |
| City | Hollywood, CA |
| Period | 6/30/02 → 7/3/02 |
Fingerprint
ASJC Scopus subject areas
- Electrical and Electronic Engineering
Cite this
Ultrashort pulse electroporation : Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. / Gundersen, Martin; Vernier, P. Thomas; Marcu, Laura; Li, Aimin; Zhu, Xhumei; Gallam, Ali Z.; Katsouleas, Thomas; Young, Clayton; Behrend, Matthew; Craft, Cheryl M.
IEEE Conference Record of Power Modulator Symposium. ed. / L. Gordon. 2002. p. 667-670.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Ultrashort pulse electroporation
T2 - Applications of high pulsed electric fields to induced caspase activation of human lymphocytes
AU - Gundersen, Martin
AU - Vernier, P. Thomas
AU - Marcu, Laura
AU - Li, Aimin
AU - Zhu, Xhumei
AU - Gallam, Ali Z.
AU - Katsouleas, Thomas
AU - Young, Clayton
AU - Behrend, Matthew
AU - Craft, Cheryl M.
PY - 2002
Y1 - 2002
N2 - This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.
AB - This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.
UR - http://www.scopus.com/inward/record.url?scp=0036999187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036999187&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0036999187
SP - 667
EP - 670
BT - IEEE Conference Record of Power Modulator Symposium
A2 - Gordon, L.
ER -