Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes

Martin Gundersen, P. Thomas Vernier, Laura Marcu, Aimin Li, Xhumei Zhu, Ali Z. Gallam, Thomas Katsouleas, Clayton Young, Matthew Behrend, Cheryl M. Craft

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Scopus citations

Abstract

This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.

Original languageEnglish (US)
Title of host publicationIEEE Conference Record of Power Modulator Symposium
EditorsL. Gordon
Pages667-670
Number of pages4
StatePublished - 2002
EventConference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop - Hollywood, CA, United States
Duration: Jun 30 2002Jul 3 2002

Other

OtherConference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop
CountryUnited States
CityHollywood, CA
Period6/30/027/3/02

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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    Gundersen, M., Vernier, P. T., Marcu, L., Li, A., Zhu, X., Gallam, A. Z., Katsouleas, T., Young, C., Behrend, M., & Craft, C. M. (2002). Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. In L. Gordon (Ed.), IEEE Conference Record of Power Modulator Symposium (pp. 667-670)