Abstract
This paper presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. lintense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.
| Original language | English (US) |
|---|---|
| Title of host publication | IEEE Conference Record of Power Modulator Symposium |
| Editors | L. Gordon |
| Pages | 667-670 |
| Number of pages | 4 |
| State | Published - 2002 |
| Event | Conference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop - Hollywood, CA, United States Duration: Jun 30 2002 → Jul 3 2002 |
Other
| Other | Conference Record of the Twenty-Fifth International Power Modulator Symposium and 2002 High-Voltage Workshop |
|---|---|
| Country | United States |
| City | Hollywood, CA |
| Period | 6/30/02 → 7/3/02 |
ASJC Scopus subject areas
- Electrical and Electronic Engineering
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Gundersen, M., Vernier, P. T., Marcu, L., Li, A., Zhu, X., Gallam, A. Z., Katsouleas, T., Young, C., Behrend, M., & Craft, C. M. (2002). Ultrashort pulse electroporation: Applications of high pulsed electric fields to induced caspase activation of human lymphocytes. In L. Gordon (Ed.), IEEE Conference Record of Power Modulator Symposium (pp. 667-670)