Ultrashort Peptides and Hyaluronic Acid-Based Injectable Composite Hydrogels for Sustained Drug Release and Chronic Diabetic Wound Healing

Ling Wang, Jing Li, Yue Xiong, Yihang Wu, Fen Yang, Ying Guo, Zhaolin Chen, Liqian Gao, Wenbin Deng

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Peptide hydrogels are widely used for biomedical applications owing to their good biocompatibility and unique advantages in terms of amino acid-based structures and functions. However, the exploration of the peptide/saccharide composite hydrogels as potential biomaterials for chronic diabetic wound healing is still limited. Herein, hyaluronic acid (HA) was incorporated into diphenylalanine (FF) conjugated with different aromatic moieties by a one-pot reaction. Our results showed that the dipeptide derivatives modified by benzene (B), naphthalene (N), and pyrene (P) self-assembled into composite hydrogels with uniform distribution and good mechanical properties in the presence of HA. The obtained N-FF/HA composite hydrogel exhibited greatly improved self-healing properties via injection syringe needle operation and good biocompatibility on human skin fibroblast (HSF) cells. Besides, the structure of thinner nanofibers and honeycomb networks inside the composite hydrogel allowed for a longer sustained release of curcumin, a hydrophobic drug for anti-inflammation and wound healing. The curcumin-loaded N-FF/HA composite hydrogels could promote chronic wound healing in the streptozotocin-induced type I diabetic mouse model. The results suggested that our developed saccharide-peptide hydrogels could serve as very promising synthetic biomaterials for applications in both drug delivery and wound healing in the future.

Original languageEnglish (US)
Pages (from-to)58329-58339
Number of pages11
JournalACS Applied Materials and Interfaces
Volume13
Issue number49
DOIs
StatePublished - Dec 15 2021
Externally publishedYes

Keywords

  • composite hydrogels
  • diabetic wound healing
  • hyaluronic acid
  • self-assembly
  • sustained drug delivery
  • ultrashort peptide

ASJC Scopus subject areas

  • Materials Science(all)

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