Ultrahigh speed spectral / fourier domain OCT imaging in ophthalmology

Benjamin Potsaid, Iwona Gorczynska, Vivek Srinivasan, Yueli Chen, Jonathan Liu, James Jiang, Alex Cable, Jay S. Duker, James G. Fujimoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ultrahigh speed Spectral/Fourier domain ophthalmic O CT imaging at 70,000-312,500 axial scans per second is dem onstrated using a high speed CM OS cam era at 800 nm. Comparative imaging results of the fovea illustrate the perform ance tradeoffs betw een different imaging speeds and spectrom eter configurations. Dense 3D volumetric acquisitions show minimal motion artifacts when acquired at 250,000 axial scans per second. The porous structure of the lam ina cribrosa is shown in en face images extracted from a dense volumetric acquisition of the optical nerve head acquired at 106, 382 axial scans per second. Rapid repeated volum e imaging (4D-OCT) show s blood flow in retinal capillaries. Boundaries of the capillary network are enhanced by motion contrast. 3D volumetric data acquired at 49,000 axial scans per second using an InGaAs cam era at 1050 nm is com pared to volumetric data acquired at 101, 010 axial scans per second using a CM OS cam era at 800nm. Averaging of adjacent cross sectional scans in the volum e is shown to increase contrast in the images and reduce speckle. The enhanced penetration of the 1050 nm com pared to the 800 nm OCT imaging system is show n. Dense 2D/3D data sets and 4D-OCT repeated volum e imaging prom ise alternative m ethods for diagnosis and m onitoring of disease.

Original languageEnglish (US)
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2009
PublisherOptical Society of America
ISBN (Print)9780819476432
StatePublished - Jan 1 2009
Externally publishedYes
EventEuropean Conference on Biomedical Optics, ECBO 2009 - Munich, Germany
Duration: Jun 14 2009Jun 18 2009

Other

OtherEuropean Conference on Biomedical Optics, ECBO 2009
CountryGermany
CityMunich
Period6/14/096/18/09

Keywords

  • Biom edical imaging
  • Ophthalmic imaging
  • Optical coherence tomography
  • Spectrom eters and spectroscopic instrum entation

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Potsaid, B., Gorczynska, I., Srinivasan, V., Chen, Y., Liu, J., Jiang, J., Cable, A., Duker, J. S., & Fujimoto, J. G. (2009). Ultrahigh speed spectral / fourier domain OCT imaging in ophthalmology. In European Conference on Biomedical Optics, ECBO 2009 Optical Society of America.