Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head

Vivek Srinivasan, Desmond C. Adler, Yueli Chen, Iwona Gorczynska, Robert Huber, Jay S. Duker, Joel S. Schuman, James G. Fujimoto

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

PURPOSE. To demonstrate ultrahigh-speed optical coherence tomography (OCT) imaging of the retina and optic nerve head at 249,000 axial scans per second and a wavelength of 1060 nm. To investigate methods for visualization of the retina, choroid, and optic nerve using high-density sampling enabled by improved imaging speed. METHODS. A swept-source OCT retinal imaging system operating at a speed of 249,000 axial scans per second was developed. Imaging of the retina, choroid, and optic nerve were performed. Display methods such as speckle reduction, slicing along arbitrary planes, en face visualization of reflectance from specific retinal layers, and image compounding were investigated. RESULTS. High-definition and three-dimensional (3D) imaging of the normal retina and optic nerve head were performed. Increased light penetration at 1060 nm enabled improved visualization of the choroid, lamina cribrosa, and sclera. OCT fundus images and 3D visualizations were generated with higher pixel density and less motion artifacts than standard spectral/Fourier domain OCT. En face images enabled visualization of the porous structure of the lamina cribrosa, nerve fiber layer, choroid, photoreceptors, RPE, and capillaries of the inner retina. CONCLUSIONS. Ultrahigh-speed OCT imaging of the retina and optic nerve head at 249,000 axial scans per second is possible. The improvement of ∼5 to 10x in imaging speed over commercial spectral/Fourier domain OCT technology enables higher density raster scan protocols and improved performance of en face visualization methods. The combination of the longer wavelength and ultrahigh imaging speed enables excellent visualization of the choroid, sclera, and lamina cribrosa.

Original languageEnglish (US)
Pages (from-to)5103-5110
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume49
Issue number11
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

Fingerprint

Optic Disk
Optical Coherence Tomography
Choroid
Retina
Sclera
Optic Nerve
Three-Dimensional Imaging
Nerve Fibers
Artifacts
Technology
Light

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. / Srinivasan, Vivek; Adler, Desmond C.; Chen, Yueli; Gorczynska, Iwona; Huber, Robert; Duker, Jay S.; Schuman, Joel S.; Fujimoto, James G.

In: Investigative Ophthalmology and Visual Science, Vol. 49, No. 11, 01.11.2008, p. 5103-5110.

Research output: Contribution to journalArticle

Srinivasan, Vivek ; Adler, Desmond C. ; Chen, Yueli ; Gorczynska, Iwona ; Huber, Robert ; Duker, Jay S. ; Schuman, Joel S. ; Fujimoto, James G. / Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. In: Investigative Ophthalmology and Visual Science. 2008 ; Vol. 49, No. 11. pp. 5103-5110.
@article{895d9d87f75b4885b7fbbd59d5fd27af,
title = "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head",
abstract = "PURPOSE. To demonstrate ultrahigh-speed optical coherence tomography (OCT) imaging of the retina and optic nerve head at 249,000 axial scans per second and a wavelength of 1060 nm. To investigate methods for visualization of the retina, choroid, and optic nerve using high-density sampling enabled by improved imaging speed. METHODS. A swept-source OCT retinal imaging system operating at a speed of 249,000 axial scans per second was developed. Imaging of the retina, choroid, and optic nerve were performed. Display methods such as speckle reduction, slicing along arbitrary planes, en face visualization of reflectance from specific retinal layers, and image compounding were investigated. RESULTS. High-definition and three-dimensional (3D) imaging of the normal retina and optic nerve head were performed. Increased light penetration at 1060 nm enabled improved visualization of the choroid, lamina cribrosa, and sclera. OCT fundus images and 3D visualizations were generated with higher pixel density and less motion artifacts than standard spectral/Fourier domain OCT. En face images enabled visualization of the porous structure of the lamina cribrosa, nerve fiber layer, choroid, photoreceptors, RPE, and capillaries of the inner retina. CONCLUSIONS. Ultrahigh-speed OCT imaging of the retina and optic nerve head at 249,000 axial scans per second is possible. The improvement of ∼5 to 10x in imaging speed over commercial spectral/Fourier domain OCT technology enables higher density raster scan protocols and improved performance of en face visualization methods. The combination of the longer wavelength and ultrahigh imaging speed enables excellent visualization of the choroid, sclera, and lamina cribrosa.",
author = "Vivek Srinivasan and Adler, {Desmond C.} and Yueli Chen and Iwona Gorczynska and Robert Huber and Duker, {Jay S.} and Schuman, {Joel S.} and Fujimoto, {James G.}",
year = "2008",
month = "11",
day = "1",
doi = "10.1167/iovs.08-2127",
language = "English (US)",
volume = "49",
pages = "5103--5110",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "11",

}

TY - JOUR

T1 - Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head

AU - Srinivasan, Vivek

AU - Adler, Desmond C.

AU - Chen, Yueli

AU - Gorczynska, Iwona

AU - Huber, Robert

AU - Duker, Jay S.

AU - Schuman, Joel S.

AU - Fujimoto, James G.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - PURPOSE. To demonstrate ultrahigh-speed optical coherence tomography (OCT) imaging of the retina and optic nerve head at 249,000 axial scans per second and a wavelength of 1060 nm. To investigate methods for visualization of the retina, choroid, and optic nerve using high-density sampling enabled by improved imaging speed. METHODS. A swept-source OCT retinal imaging system operating at a speed of 249,000 axial scans per second was developed. Imaging of the retina, choroid, and optic nerve were performed. Display methods such as speckle reduction, slicing along arbitrary planes, en face visualization of reflectance from specific retinal layers, and image compounding were investigated. RESULTS. High-definition and three-dimensional (3D) imaging of the normal retina and optic nerve head were performed. Increased light penetration at 1060 nm enabled improved visualization of the choroid, lamina cribrosa, and sclera. OCT fundus images and 3D visualizations were generated with higher pixel density and less motion artifacts than standard spectral/Fourier domain OCT. En face images enabled visualization of the porous structure of the lamina cribrosa, nerve fiber layer, choroid, photoreceptors, RPE, and capillaries of the inner retina. CONCLUSIONS. Ultrahigh-speed OCT imaging of the retina and optic nerve head at 249,000 axial scans per second is possible. The improvement of ∼5 to 10x in imaging speed over commercial spectral/Fourier domain OCT technology enables higher density raster scan protocols and improved performance of en face visualization methods. The combination of the longer wavelength and ultrahigh imaging speed enables excellent visualization of the choroid, sclera, and lamina cribrosa.

AB - PURPOSE. To demonstrate ultrahigh-speed optical coherence tomography (OCT) imaging of the retina and optic nerve head at 249,000 axial scans per second and a wavelength of 1060 nm. To investigate methods for visualization of the retina, choroid, and optic nerve using high-density sampling enabled by improved imaging speed. METHODS. A swept-source OCT retinal imaging system operating at a speed of 249,000 axial scans per second was developed. Imaging of the retina, choroid, and optic nerve were performed. Display methods such as speckle reduction, slicing along arbitrary planes, en face visualization of reflectance from specific retinal layers, and image compounding were investigated. RESULTS. High-definition and three-dimensional (3D) imaging of the normal retina and optic nerve head were performed. Increased light penetration at 1060 nm enabled improved visualization of the choroid, lamina cribrosa, and sclera. OCT fundus images and 3D visualizations were generated with higher pixel density and less motion artifacts than standard spectral/Fourier domain OCT. En face images enabled visualization of the porous structure of the lamina cribrosa, nerve fiber layer, choroid, photoreceptors, RPE, and capillaries of the inner retina. CONCLUSIONS. Ultrahigh-speed OCT imaging of the retina and optic nerve head at 249,000 axial scans per second is possible. The improvement of ∼5 to 10x in imaging speed over commercial spectral/Fourier domain OCT technology enables higher density raster scan protocols and improved performance of en face visualization methods. The combination of the longer wavelength and ultrahigh imaging speed enables excellent visualization of the choroid, sclera, and lamina cribrosa.

UR - http://www.scopus.com/inward/record.url?scp=56149105399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56149105399&partnerID=8YFLogxK

U2 - 10.1167/iovs.08-2127

DO - 10.1167/iovs.08-2127

M3 - Article

C2 - 18658089

AN - SCOPUS:56149105399

VL - 49

SP - 5103

EP - 5110

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 11

ER -