Ultrahigh speed imaging of the rat retina using ultrahigh resolution spectral / Fourier domain OCT

Jonathan J. Liu; Benjamin Potsaid; Yueli Chen; Iwona Gorczynska; Vivek Srinivasan; Jay S. Duker; James G. Fujimoto

doi:10.1117/12.842540

Ultrahigh speed imaging of the rat retina using ultrahigh resolution spectral / Fourier domain OCT

Jonathan J. Liu, Benjamin Potsaid, Yueli Chen, Iwona Gorczynska, Vivek Srinivasan, Jay S. Duker, James G. Fujimoto

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We performed OCT imaging of the rat retina at 70,000 axial scans per second with ∼3 μm axial resolution. Three-dimensional OCT (3D-OCT) data sets of the rat retina were acquired. The high speed and high density data sets enable improved en face visualization by reducing eye motion artifacts and improve Doppler OCT measurements. Minimal motion artifacts were visible and the OCT fundus images offer more precise registration of individual OCT images to retinal fundus features. Projection OCT fundus images show features such as the nerve fiber layer, retinal capillary networks and choroidal vasculature. Doppler OCT images and quantitative measurements show pulsatility in retinal blood vessels. Doppler OCT provides non-invasive in vivo quantitative measurements of retinal blood flow properties and may benefit studies of diseases such as glaucoma and diabetic retinopathy. Ultrahigh speed imaging using ultrahigh resolution spectral / Fourier domain OCT promises to enable novel protocols for measuring small animal retinal structure and retinal blood flow. This non-invasive imaging technology is a promising tool for monitoring disease progression in rat and mouse models to assess ocular disease pathogenesis and response to treatment.

Original language	English (US)
Title of host publication	Ophthalmic Technologies XX
Volume	7550
DOIs	https://doi.org/10.1117/12.842540
State	Published - Dec 1 2010
Externally published	Yes
Event	Ophthalmic Technologies XX - San Francisco, CA, United States Duration: Jan 23 2010 → Jan 25 2010

Other

Other	Ophthalmic Technologies XX
Country/Territory	United States
City	San Francisco, CA
Period	1/23/10 → 1/25/10

Keywords

Doppler OCT
Small animal imaging
Spectral/Fourier domain OCT
Ultrahigh resolution OCT
Ultrahigh speed OCT

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

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10.1117/12.842540

Cite this

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title = "Ultrahigh speed imaging of the rat retina using ultrahigh resolution spectral / Fourier domain OCT",

abstract = "We performed OCT imaging of the rat retina at 70,000 axial scans per second with ∼3 μm axial resolution. Three-dimensional OCT (3D-OCT) data sets of the rat retina were acquired. The high speed and high density data sets enable improved en face visualization by reducing eye motion artifacts and improve Doppler OCT measurements. Minimal motion artifacts were visible and the OCT fundus images offer more precise registration of individual OCT images to retinal fundus features. Projection OCT fundus images show features such as the nerve fiber layer, retinal capillary networks and choroidal vasculature. Doppler OCT images and quantitative measurements show pulsatility in retinal blood vessels. Doppler OCT provides non-invasive in vivo quantitative measurements of retinal blood flow properties and may benefit studies of diseases such as glaucoma and diabetic retinopathy. Ultrahigh speed imaging using ultrahigh resolution spectral / Fourier domain OCT promises to enable novel protocols for measuring small animal retinal structure and retinal blood flow. This non-invasive imaging technology is a promising tool for monitoring disease progression in rat and mouse models to assess ocular disease pathogenesis and response to treatment.",

keywords = "Doppler OCT, Small animal imaging, Spectral/Fourier domain OCT, Ultrahigh resolution OCT, Ultrahigh speed OCT",

author = "Liu, {Jonathan J.} and Benjamin Potsaid and Yueli Chen and Iwona Gorczynska and Vivek Srinivasan and Duker, {Jay S.} and Fujimoto, {James G.}",

year = "2010",

month = dec,

day = "1",

doi = "10.1117/12.842540",

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AU - Liu, Jonathan J.

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AU - Chen, Yueli

AU - Gorczynska, Iwona

AU - Srinivasan, Vivek

AU - Duker, Jay S.

AU - Fujimoto, James G.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - We performed OCT imaging of the rat retina at 70,000 axial scans per second with ∼3 μm axial resolution. Three-dimensional OCT (3D-OCT) data sets of the rat retina were acquired. The high speed and high density data sets enable improved en face visualization by reducing eye motion artifacts and improve Doppler OCT measurements. Minimal motion artifacts were visible and the OCT fundus images offer more precise registration of individual OCT images to retinal fundus features. Projection OCT fundus images show features such as the nerve fiber layer, retinal capillary networks and choroidal vasculature. Doppler OCT images and quantitative measurements show pulsatility in retinal blood vessels. Doppler OCT provides non-invasive in vivo quantitative measurements of retinal blood flow properties and may benefit studies of diseases such as glaucoma and diabetic retinopathy. Ultrahigh speed imaging using ultrahigh resolution spectral / Fourier domain OCT promises to enable novel protocols for measuring small animal retinal structure and retinal blood flow. This non-invasive imaging technology is a promising tool for monitoring disease progression in rat and mouse models to assess ocular disease pathogenesis and response to treatment.

AB - We performed OCT imaging of the rat retina at 70,000 axial scans per second with ∼3 μm axial resolution. Three-dimensional OCT (3D-OCT) data sets of the rat retina were acquired. The high speed and high density data sets enable improved en face visualization by reducing eye motion artifacts and improve Doppler OCT measurements. Minimal motion artifacts were visible and the OCT fundus images offer more precise registration of individual OCT images to retinal fundus features. Projection OCT fundus images show features such as the nerve fiber layer, retinal capillary networks and choroidal vasculature. Doppler OCT images and quantitative measurements show pulsatility in retinal blood vessels. Doppler OCT provides non-invasive in vivo quantitative measurements of retinal blood flow properties and may benefit studies of diseases such as glaucoma and diabetic retinopathy. Ultrahigh speed imaging using ultrahigh resolution spectral / Fourier domain OCT promises to enable novel protocols for measuring small animal retinal structure and retinal blood flow. This non-invasive imaging technology is a promising tool for monitoring disease progression in rat and mouse models to assess ocular disease pathogenesis and response to treatment.

KW - Doppler OCT

KW - Small animal imaging

KW - Spectral/Fourier domain OCT

KW - Ultrahigh resolution OCT

KW - Ultrahigh speed OCT

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Ultrahigh speed imaging of the rat retina using ultrahigh resolution spectral / Fourier domain OCT

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Keywords

ASJC Scopus subject areas

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