Ultrahigh resolution retinal imaging by visible light OCT with longitudinal achromatization

Shau Poh Chong, Tingwei Zhang, Aaron Kho, Marcel T. Bernucci, Alfredo Dubra, Vivek Srinivasan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Chromatic aberrations are an important design consideration in high resolution, high bandwidth, refractive imaging systems that use visible light. Here, we present a fiberbased spectral/Fourier domain, visible light OCT ophthalmoscope corrected for the average longitudinal chromatic aberration (LCA) of the human eye. Analysis of complex speckles from in vivo retinal images showed that achromatization resulted in a speckle autocorrelation function that was ~20% narrower in the axial direction, but unchanged in the transverse direction. In images from the improved, achromatized system, the separation between Bruch’s membrane (BM), the retinal pigment epithelium (RPE), and the outer segment tips clearly emerged across the entire 6.5 mm field-of-view, enabling segmentation and morphometry of BM and the RPE in a human subject. Finally, cross-sectional images depicted distinct inner retinal layers with high resolution. Thus, with chromatic aberration compensation, visible light OCT can achieve volume resolutions and retinal image quality that matches or exceeds ultrahigh resolution near-infrared OCT systems with no monochromatic aberration compensation.

Original languageEnglish (US)
Article number#308920
Pages (from-to)1477-1491
Number of pages15
JournalBiomedical Optics Express
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2018

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Bruch Membrane
aberration
Retinal Pigment Epithelium
Color
retinal images
Light
epithelium
pigments
Ophthalmoscopes
membranes
high resolution
image resolution
autocorrelation
field of view
bandwidth
Direction compound

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Ultrahigh resolution retinal imaging by visible light OCT with longitudinal achromatization. / Chong, Shau Poh; Zhang, Tingwei; Kho, Aaron; Bernucci, Marcel T.; Dubra, Alfredo; Srinivasan, Vivek.

In: Biomedical Optics Express, Vol. 9, No. 4, #308920, 01.04.2018, p. 1477-1491.

Research output: Contribution to journalArticle

Chong, Shau Poh ; Zhang, Tingwei ; Kho, Aaron ; Bernucci, Marcel T. ; Dubra, Alfredo ; Srinivasan, Vivek. / Ultrahigh resolution retinal imaging by visible light OCT with longitudinal achromatization. In: Biomedical Optics Express. 2018 ; Vol. 9, No. 4. pp. 1477-1491.
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