Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation

Maciej Wojtkowski, Vivek Srinivasan, Tony H. Ko, James G. Fujimoto, Andrzej Kowalczyk, Jay S. Duker

Research output: Contribution to journalArticle

858 Scopus citations

Abstract

Ultrahigh-resolution optical coherence tomography uses broadband light sources to achieve axial image resolutions on the few micron scale. Fourier domain detection methods enable more than an order of magnitude increase in imaging speed and sensitivity, thus overcoming the sensitivity limitations inherent in ultrahigh-resolution OCT using standard time domain detection. Fourier domain methods also provide direct access to the spectrum of the optical signal. This enables automatic numerical dispersion compensation, a key factor in achieving ultrahigh image resolutions. We present ultrahigh-resolution, high-speed Fourier domain OCT imaging with an axial resolution of 2.1 μm in tissue and 16,000 axial scans per second at 1024 pixels per axial scan. Ultrahigh-resolution spectral domain OCT is shown to provide a ∼100x increase in imaging speed when compared to ultrahigh-resolution time domain OCT. In vivo imaging of the human retina is demonstrated. We also present a general technique for automatic numerical dispersion compensation, which is applicable to spectral domain as well as swept source embodiments of Fourier domain OCT.

Original languageEnglish (US)
Pages (from-to)2404-2422
Number of pages19
JournalOptics Express
Volume12
Issue number11
DOIs
StatePublished - May 31 2004
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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