Ultrahigh-Resolution Adaptive Optics - Optical Coherence Tomography: Towards isotropic 3 μm resolution for in vivo retinal imaging

Robert Zawadzki, Yan Zhang, Steven M. Jones, R. Daniel Ferguson, Stacey S. Choi, Barry Cense, Julia W. Evans, Diana Chen, Donald T. Miller, Scot S. Olivier, John S Werner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Ultrahigh axial resolution in adaptive optics - optical coherence tomography (AO-OCT) is fundamentally limited by the intrinsic chromatic aberrations of the human eye. Variation in refractive index of the ocular media with wavelength causes the spectral content of broadband light sources to focus at different depths in the retina for light entering the eye and at the imaging detector for light exiting. This effect has not been previously reported for ultrahigh-resolution OCT (without AO) likely because the effect is masked by the relatively long depth of focus dictated by the small pupils used in these systems. With AO, the pupil size is much larger and depth of focus substantially narrower. As such the chromatic aberrations of the eye can counteract the lateral resolution benefit of AO when used with broadband light sources. To more fully tap the potential of AO-OCT, compensation of the eye's chromatic and monochromatic aberrations must occur concurrently. One solution is to insert an achromatizing lens in front of the eye whose chromatic aberrations are equal but opposite in sign to that of the eye. In this paper we evaluate the efficacy of a novel design that uses a custom achromatizing lens placed near the fiber collimating optic. AO-OCT images are acquired on several subjects with and without the achromatizing lens and in combination with two light sources of different spectral width. The combination of the achromatizing lens and broadband light source yielded the sharpest images of the retina and the smallest speckle.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6429
DOIs
StatePublished - 2007
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI - San Jose, CA, United States
Duration: Jan 22 2007Jan 24 2007

Other

OtherCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI
CountryUnited States
CitySan Jose, CA
Period1/22/071/24/07

Keywords

  • (010.1080) Adaptive optics
  • (110.4500) Optical coherence tomography
  • (120.3890) Medical optics instrumentation
  • (170.0110) imaging system
  • (170.4470) ophthalmology
  • (220.1000) Aberration compensation

ASJC Scopus subject areas

  • Engineering(all)

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    Zawadzki, R., Zhang, Y., Jones, S. M., Ferguson, R. D., Choi, S. S., Cense, B., Evans, J. W., Chen, D., Miller, D. T., Olivier, S. S., & Werner, J. S. (2007). Ultrahigh-Resolution Adaptive Optics - Optical Coherence Tomography: Towards isotropic 3 μm resolution for in vivo retinal imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6429). [642909] https://doi.org/10.1117/12.704639