Ultrafiltrate and total platinum in plasma and cerebrospinal fluid in a patient with neuroblastoma

M. W. DeGregorio, O. Y. King, W. M. Holleran, B. J. Wilbur, E. C. Cadman, A. B. Deisseroth, J. R. Wilbur

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Ultrafiltrate and total plasma and cerebrospinal fluid (CSF) platinum concentrations were examined in a patient with neuroblastoma following a 2-hour infusion of 120 mg/m2 of cisplatin. Total plasma platinum was 93.4% bound, while the ultrafiltrate of plasma accounted for the remaining 6.6%. The CSF ultrafiltrate resulted in equivalent concentrations of platinum to total CSF platinum. CSF concentrations were 2.9% of the total plasma platinum and 43.5% of the ultrafiltrate plasma platinum 2 hours after the end of the infusion.

Original languageEnglish (US)
Pages (from-to)1441-1442
Number of pages2
JournalCancer Treatment Reports
Volume69
Issue number12
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    DeGregorio, M. W., King, O. Y., Holleran, W. M., Wilbur, B. J., Cadman, E. C., Deisseroth, A. B., & Wilbur, J. R. (1985). Ultrafiltrate and total platinum in plasma and cerebrospinal fluid in a patient with neuroblastoma. Cancer Treatment Reports, 69(12), 1441-1442.