Ultrafiltrate and total platinum in plasma and cerebrospinal fluid in a patient with neuroblastoma

M. W. DeGregorio; O. Y. King; W. M. Holleran; B. J. Wilbur; E. C. Cadman; A. B. Deisseroth; J. R. Wilbur

Ultrafiltrate and total platinum in plasma and cerebrospinal fluid in a patient with neuroblastoma

M. W. DeGregorio, O. Y. King, W. M. Holleran, B. J. Wilbur, E. C. Cadman, A. B. Deisseroth, J. R. Wilbur

Research output: Contribution to journal › Article › peer-review

Abstract

Ultrafiltrate and total plasma and cerebrospinal fluid (CSF) platinum concentrations were examined in a patient with neuroblastoma following a 2-hour infusion of 120 mg/m² of cisplatin. Total plasma platinum was 93.4% bound, while the ultrafiltrate of plasma accounted for the remaining 6.6%. The CSF ultrafiltrate resulted in equivalent concentrations of platinum to total CSF platinum. CSF concentrations were 2.9% of the total plasma platinum and 43.5% of the ultrafiltrate plasma platinum 2 hours after the end of the infusion.

Original language	English (US)
Pages (from-to)	1441-1442
Number of pages	2
Journal	Cancer Treatment Reports
Volume	69
Issue number	12
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Oncology

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title = "Ultrafiltrate and total platinum in plasma and cerebrospinal fluid in a patient with neuroblastoma",

abstract = "Ultrafiltrate and total plasma and cerebrospinal fluid (CSF) platinum concentrations were examined in a patient with neuroblastoma following a 2-hour infusion of 120 mg/m2 of cisplatin. Total plasma platinum was 93.4% bound, while the ultrafiltrate of plasma accounted for the remaining 6.6%. The CSF ultrafiltrate resulted in equivalent concentrations of platinum to total CSF platinum. CSF concentrations were 2.9% of the total plasma platinum and 43.5% of the ultrafiltrate plasma platinum 2 hours after the end of the infusion.",

author = "DeGregorio, {M. W.} and King, {O. Y.} and Holleran, {W. M.} and Wilbur, {B. J.} and Cadman, {E. C.} and Deisseroth, {A. B.} and Wilbur, {J. R.}",

year = "1985",

language = "English (US)",

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AU - DeGregorio, M. W.

AU - King, O. Y.

AU - Holleran, W. M.

AU - Wilbur, B. J.

AU - Cadman, E. C.

AU - Deisseroth, A. B.

AU - Wilbur, J. R.

PY - 1985

Y1 - 1985

N2 - Ultrafiltrate and total plasma and cerebrospinal fluid (CSF) platinum concentrations were examined in a patient with neuroblastoma following a 2-hour infusion of 120 mg/m2 of cisplatin. Total plasma platinum was 93.4% bound, while the ultrafiltrate of plasma accounted for the remaining 6.6%. The CSF ultrafiltrate resulted in equivalent concentrations of platinum to total CSF platinum. CSF concentrations were 2.9% of the total plasma platinum and 43.5% of the ultrafiltrate plasma platinum 2 hours after the end of the infusion.

AB - Ultrafiltrate and total plasma and cerebrospinal fluid (CSF) platinum concentrations were examined in a patient with neuroblastoma following a 2-hour infusion of 120 mg/m2 of cisplatin. Total plasma platinum was 93.4% bound, while the ultrafiltrate of plasma accounted for the remaining 6.6%. The CSF ultrafiltrate resulted in equivalent concentrations of platinum to total CSF platinum. CSF concentrations were 2.9% of the total plasma platinum and 43.5% of the ultrafiltrate plasma platinum 2 hours after the end of the infusion.

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JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 12

ER -

Ultrafiltrate and total platinum in plasma and cerebrospinal fluid in a patient with neuroblastoma

Abstract

ASJC Scopus subject areas

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