Ultra-high resolution adaptive optics - Optical coherence tomography for in vivo imaging of healthy and diseased retinal structures

Robert Zawadzki, Yan Zhang, Steven M. Jones, Stacey S. Choi, Barry Cense, Julia W. Evans, Donald T. Miller, Scot S. Olivier, John S Werner

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Ultra-high isotropic resolution imaging of retinal structures was made possible with an adaptive optics system using dual deformable mirrors and a Fourier-domain optical coherence tomography (Fd-OCT) system with correction for longitudinal chromatic aberration. This system was used to image microscopic retinal structures of healthy as well as diseased retinas in vivo. The improved resolution and contrast enhanced visualization of morphological structures in the retina can be clearly seen. The benefits of this instrument are apparent from comparison of new images with those acquired using a previous generation AO-OCT instrument. Big change in the appearance of speckle field (reduction in speckle size) can be observed as well. Additionally, further improvements in volumetric data acquisition and image representation will be discussed. This includes creation of large Field of View (FOV) AO-OCT volume from multiple sub-volumes and its visualization. Also techniques and results of reducing speckle contrast by averaging multiple B-scans will be presented.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2008
EventOphthalmic Technologies XVIII - San Jose, CA, United States
Duration: Jan 19 2008Jan 21 2008


OtherOphthalmic Technologies XVIII
Country/TerritoryUnited States
CitySan Jose, CA


  • (010.1080) adaptive optics
  • (110.4500) optical coherence tomography
  • (120.3890) medical optics instrumentation
  • (170.0110) imaging system
  • (170.4470) ophthalmology
  • (220.1000) aberration compensation

ASJC Scopus subject areas

  • Engineering(all)


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