Abstract
UK-73,093 was identified in a screening program as a compound able to displace [3H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1535-1540 |
| Number of pages | 6 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 2 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
UK-73,093 : A non-peptide neurotensin receptor antagonist. / Snider, R. Michael; Pereira, Dennis A.; Longo, Kelly P.; Davidson, Ralph E.; Vinick, Frederic J.; Laitinen, Kirsti; Genc-Sehitoglu, Ece; Crawley, Jacqueline.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 2, No. 12, 1992, p. 1535-1540.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - UK-73,093
T2 - A non-peptide neurotensin receptor antagonist
AU - Snider, R. Michael
AU - Pereira, Dennis A.
AU - Longo, Kelly P.
AU - Davidson, Ralph E.
AU - Vinick, Frederic J.
AU - Laitinen, Kirsti
AU - Genc-Sehitoglu, Ece
AU - Crawley, Jacqueline
PY - 1992
Y1 - 1992
N2 - UK-73,093 was identified in a screening program as a compound able to displace [3H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo.
AB - UK-73,093 was identified in a screening program as a compound able to displace [3H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0026716855&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026716855&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(00)80423-0
DO - 10.1016/S0960-894X(00)80423-0
M3 - Article
AN - SCOPUS:0026716855
VL - 2
SP - 1535
EP - 1540
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 12
ER -