UK-73,093: A non-peptide neurotensin receptor antagonist

R. Michael Snider, Dennis A. Pereira, Kelly P. Longo, Ralph E. Davidson, Frederic J. Vinick, Kirsti Laitinen, Ece Genc-Sehitoglu, Jacqueline Crawley

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

UK-73,093 was identified in a screening program as a compound able to displace [3H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)1535-1540
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number12
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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  • Cite this

    Snider, R. M., Pereira, D. A., Longo, K. P., Davidson, R. E., Vinick, F. J., Laitinen, K., Genc-Sehitoglu, E., & Crawley, J. (1992). UK-73,093: A non-peptide neurotensin receptor antagonist. Bioorganic and Medicinal Chemistry Letters, 2(12), 1535-1540. https://doi.org/10.1016/S0960-894X(00)80423-0