UK-73,093: A non-peptide neurotensin receptor antagonist

R. Michael Snider; Dennis A. Pereira; Kelly P. Longo; Ralph E. Davidson; Frederic J. Vinick; Kirsti Laitinen; Ece Genc-Sehitoglu; Jacqueline Crawley

doi:10.1016/S0960-894X(00)80423-0

UK-73,093: A non-peptide neurotensin receptor antagonist

R. Michael Snider, Dennis A. Pereira, Kelly P. Longo, Ralph E. Davidson, Frederic J. Vinick, Kirsti Laitinen, Ece Genc-Sehitoglu, Jacqueline Crawley

Research output: Contribution to journal › Article

20 Scopus citations

Abstract

UK-73,093 was identified in a screening program as a compound able to displace [³H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo.

Original language	English (US)
Pages (from-to)	1535-1540
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(00)80423-0
State	Published - 1992
Externally published	Yes

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ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Cite this

Snider, R. M., Pereira, D. A., Longo, K. P., Davidson, R. E., Vinick, F. J., Laitinen, K., Genc-Sehitoglu, E., & Crawley, J. (1992). UK-73,093: A non-peptide neurotensin receptor antagonist. Bioorganic and Medicinal Chemistry Letters, 2(12), 1535-1540. https://doi.org/10.1016/S0960-894X(00)80423-0

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AU - Longo, Kelly P.

AU - Davidson, Ralph E.

AU - Vinick, Frederic J.

AU - Laitinen, Kirsti

AU - Genc-Sehitoglu, Ece

AU - Crawley, Jacqueline

PY - 1992

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Access to Document

10.1016/S0960-894X(00)80423-0