UK-73,093

A non-peptide neurotensin receptor antagonist

R. Michael Snider, Dennis A. Pereira, Kelly P. Longo, Ralph E. Davidson, Frederic J. Vinick, Kirsti Laitinen, Ece Genc-Sehitoglu, Jacqueline Crawley

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

UK-73,093 was identified in a screening program as a compound able to displace [3H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)1535-1540
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number12
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Neurotensin Receptors
Neurotensin
Brain
Screening

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Snider, R. M., Pereira, D. A., Longo, K. P., Davidson, R. E., Vinick, F. J., Laitinen, K., ... Crawley, J. (1992). UK-73,093: A non-peptide neurotensin receptor antagonist. Bioorganic and Medicinal Chemistry Letters, 2(12), 1535-1540. https://doi.org/10.1016/S0960-894X(00)80423-0

UK-73,093 : A non-peptide neurotensin receptor antagonist. / Snider, R. Michael; Pereira, Dennis A.; Longo, Kelly P.; Davidson, Ralph E.; Vinick, Frederic J.; Laitinen, Kirsti; Genc-Sehitoglu, Ece; Crawley, Jacqueline.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 2, No. 12, 1992, p. 1535-1540.

Research output: Contribution to journalArticle

Snider, RM, Pereira, DA, Longo, KP, Davidson, RE, Vinick, FJ, Laitinen, K, Genc-Sehitoglu, E & Crawley, J 1992, 'UK-73,093: A non-peptide neurotensin receptor antagonist', Bioorganic and Medicinal Chemistry Letters, vol. 2, no. 12, pp. 1535-1540. https://doi.org/10.1016/S0960-894X(00)80423-0
Snider RM, Pereira DA, Longo KP, Davidson RE, Vinick FJ, Laitinen K et al. UK-73,093: A non-peptide neurotensin receptor antagonist. Bioorganic and Medicinal Chemistry Letters. 1992;2(12):1535-1540. https://doi.org/10.1016/S0960-894X(00)80423-0
Snider, R. Michael ; Pereira, Dennis A. ; Longo, Kelly P. ; Davidson, Ralph E. ; Vinick, Frederic J. ; Laitinen, Kirsti ; Genc-Sehitoglu, Ece ; Crawley, Jacqueline. / UK-73,093 : A non-peptide neurotensin receptor antagonist. In: Bioorganic and Medicinal Chemistry Letters. 1992 ; Vol. 2, No. 12. pp. 1535-1540.
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