UK-73,093: A non-peptide neurotensin receptor antagonist

R. Michael Snider; Dennis A. Pereira; Kelly P. Longo; Ralph E. Davidson; Frederic J. Vinick; Kirsti Laitinen; Ece Genc-Sehitoglu; Jacqueline Crawley

doi:10.1016/S0960-894X(00)80423-0

UK-73,093: A non-peptide neurotensin receptor antagonist

R. Michael Snider, Dennis A. Pereira, Kelly P. Longo, Ralph E. Davidson, Frederic J. Vinick, Kirsti Laitinen, Ece Genc-Sehitoglu, Jacqueline Crawley

Research output: Contribution to journal › Article

20 Scopus citations

Abstract

UK-73,093 was identified in a screening program as a compound able to displace [³H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo.

Original language	English (US)
Pages (from-to)	1535-1540
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(00)80423-0
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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10.1016/S0960-894X(00)80423-0

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Snider, R. M., Pereira, D. A., Longo, K. P., Davidson, R. E., Vinick, F. J., Laitinen, K., Genc-Sehitoglu, E., & Crawley, J. (1992). UK-73,093: A non-peptide neurotensin receptor antagonist. Bioorganic and Medicinal Chemistry Letters, 2(12), 1535-1540. https://doi.org/10.1016/S0960-894X(00)80423-0

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abstract = "UK-73,093 was identified in a screening program as a compound able to displace [3H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo.",

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AU - Pereira, Dennis A.

AU - Longo, Kelly P.

AU - Davidson, Ralph E.

AU - Vinick, Frederic J.

AU - Laitinen, Kirsti

AU - Genc-Sehitoglu, Ece

AU - Crawley, Jacqueline

PY - 1992

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