Ubiquitous, interspersed repeated sequences in mammalian genomes

W. R. Jelinek, T. P. Toomey, L. Leinwand, C. H. Duncan, P. A. Biro, Prabhakara V Choudary, S. M. Weissman, C. M. Rubin, C. M. Houck, P. L. Deininger, C. W. Schmid

Research output: Contribution to journalArticle

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Abstract

DNA base sequence comparisons demonstrate that the principal family of 300-nucleotide interspersed human DNA sequences, the repetitive double-strand regions of HeLa cell heterogeneous nuclear RNA, and specific RNA polymerase III in vitro transcripts of cloned human DNA sequences are all representatives of a closely related family of sequences. A segment of approximately 30 residues of these sequences is highly conserved in mammalian evolution because it is also present in the interspersed repeated DNA sequences of Chinese hamsters. Further DNA sequence comparisons demonstrate that a portion of this highly conserved segment of repetitive mammalian DNA sequence is similar to a sequence found within a low molecular weight RNA that hydrogen-bonds to poly(A)-terminated RNA molecules of Chinese hamsters and a sequence that forms half of a perfect inverted repeat near the origin of DNA replication in papovaviruses.

Original languageEnglish (US)
Pages (from-to)1398-1402
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume77
Issue number3 I
StatePublished - 1980
Externally publishedYes

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Genome
Cricetulus
Heterogeneous Nuclear RNA
RNA Polymerase III
Replication Origin
DNA Replication
HeLa Cells
Hydrogen
Nucleotides
Molecular Weight
RNA
Messenger RNA

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Jelinek, W. R., Toomey, T. P., Leinwand, L., Duncan, C. H., Biro, P. A., Choudary, P. V., ... Schmid, C. W. (1980). Ubiquitous, interspersed repeated sequences in mammalian genomes. Proceedings of the National Academy of Sciences of the United States of America, 77(3 I), 1398-1402.

Ubiquitous, interspersed repeated sequences in mammalian genomes. / Jelinek, W. R.; Toomey, T. P.; Leinwand, L.; Duncan, C. H.; Biro, P. A.; Choudary, Prabhakara V; Weissman, S. M.; Rubin, C. M.; Houck, C. M.; Deininger, P. L.; Schmid, C. W.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 77, No. 3 I, 1980, p. 1398-1402.

Research output: Contribution to journalArticle

Jelinek, WR, Toomey, TP, Leinwand, L, Duncan, CH, Biro, PA, Choudary, PV, Weissman, SM, Rubin, CM, Houck, CM, Deininger, PL & Schmid, CW 1980, 'Ubiquitous, interspersed repeated sequences in mammalian genomes', Proceedings of the National Academy of Sciences of the United States of America, vol. 77, no. 3 I, pp. 1398-1402.
Jelinek WR, Toomey TP, Leinwand L, Duncan CH, Biro PA, Choudary PV et al. Ubiquitous, interspersed repeated sequences in mammalian genomes. Proceedings of the National Academy of Sciences of the United States of America. 1980;77(3 I):1398-1402.
Jelinek, W. R. ; Toomey, T. P. ; Leinwand, L. ; Duncan, C. H. ; Biro, P. A. ; Choudary, Prabhakara V ; Weissman, S. M. ; Rubin, C. M. ; Houck, C. M. ; Deininger, P. L. ; Schmid, C. W. / Ubiquitous, interspersed repeated sequences in mammalian genomes. In: Proceedings of the National Academy of Sciences of the United States of America. 1980 ; Vol. 77, No. 3 I. pp. 1398-1402.
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